The emergence and spread of antibiotic resistant strains particularly the detection of the Extended Spectrum Beta-lactamases (ESBLs) Salmonella species, is fast becoming an emerging world threat. ESBLs frequently occur in K. pneumoniae but recent studies have increasingly reported its occurrence in the Salmonella specie and other gram-negative organisms. Such Salmonella strains pose significant health problems worldwide by virtue of their acquisition of resistance against most beta-lactam antibiotics, which were previously used for treatment of Salmonella infections.