Oral hygiene is the main portal for the body health most crucial component of our overall general health. It is a determinant factor for life quality as both are associated strongly. The data mined about oral health from Global Burden of Disease Study in 2018 revealed that oral diseases are affect nearly 3.5 billion people globally, which can pose a serious health charge for many countries and affect individuals throughout their lifetime and influencing sleep, eating habits, and social factors. Oral hygiene is diminished by many pathogenic microbes which affected the oral region by various damages that they may expand and cause serious disease. Therefore, prevention and take control of oral pathogens is an important factor to maintain good oral hygiene several traditional medicinal plants have been proven for their activity and use in the prevention and treatment of different oral diseases. Natural products have a unique diversity in chemical structure responsible for their pharmacological activities which in most cases are due to combined effects of the active constituents within the medicinal plant. Historically, the first known natural product for oral hygiene tool was the chewing stick, the Mistake, derived mainly from Arak tree that grows in Saudi Arabia.

It is obtained from (Salvadoran Persia L.) of the family Salvadoraceae, widespread in Middle Eastern, some Asian and African cultures traditionally utilize it as tooth-powder and tooth-cleaner. The World Health Organization (WHO) recommended the use of Mistake in 1986 and in 2000 in an international consensus report on oral hygiene. S. persona has antibacterial activity; antifungal properties; antiviral activity; dental plaque control; antioxidant; antilipidemic and antidiuretic activity. The major active constituents isolated from stem of S. Persia for good oral hygiene are tannins, silica, alkaloids, volatile oil, sulphuryl monocline, organic sulphuryl compounds, chlorides, calcium, β-sit sterol and saponins. Lozenges are dosage forms manufactured in a simple way, which can deliver an active ingredient as they disintegrate slowly in the oral cavity. Lozenges considerable has advantages over oral sprays or gargles, which provide fast, effective and sustainable delivery of active ingredients representing a good vehicle for active constituents, therefore highlighting their potential benefits for mouth and throat medication with palatable mean and high patient adherence.

Two standard model of hard candy lozenges formula based on different excipients were prepared by heating and congealing technique. The compositions of model formulations are given. For formula I, the candy base was prepared by dissolving of fine powder sugar in one-third amount of distilled water in candy base cooker. This had been continued till the temperature reached 200°C. Liquid glucose was then poured slowly and temperature antibacterial and antifungal activities of S. persona aqueous extract and S. persica aqueous extract lozenges were determined using the well diffusion method. Petri plates containing 20 ml of, nutrient agar for bacteria (Darwin Biological, UK) or malt extract for fungus (HI media, India), agar medium was seeded with 1-3 days culturesof microbial inoculums. Wells (6 mm in diameter) were cut off from agar and 50 µl of the samples in different concentrations and standard antibiotics were tested and then incubated at 37°C for 24-48 hours (bacterial strains) and for 3-5 days (fungal strain).The antibacterial and antifungal activities were determined by measurement of the diameter of the inhibition zone surrounding.

Best Regards,
Nancy Ella
Associate Managing Editor
Drug Designing: Open Access