The Transient Receptor Potential (TRP) channels compromise a superfamily of polymodal receptors that are critically involved in the detection of diverse stimuli such as temperature or pH changes, noxious chemicals or mechanical forces. This ability to sense environmental changes is essential for survival, and thus the disruption of TRP channel function can have a severe impact on human health, as evidenced by the increasing number of hereditary and acquired diseases linked to TRP channels. Many members of the TRP channel superfamily are expressed in the brain. However, their role is not restricted in sensing brain microenvironmental changes and seems quite complex. Indeed, TRP channels expressed in neuronal, glial or endothelial cells have been shown to regulate many aspects of brain physiology such as neural network formation or synaptic transmission.
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Journal of Medical and surgical pathology