The implantable drug delivery system (IDDS) is a medical device that can be surgically placed inside patient tissues to introduce a therapeutic substance and improve its efficacy and safety by controlling the rate, time, and place of drug release in the body . IDDS represents a smart interface between the biological target and the drug depot. Importantly, for the regulatory purposes, IDDSs are combination products that merge two or more regulated components such as drugs, medical devices, or biological products that function as a single entityEye treatment can be done by variety of implantable systems, including membrane activating devices, implantable silicone devices, and implantable infusion systems, have been studied to provide long-term ocular drug delivery Ocusert, which contains a pilocarpine base and alginic acid in a drug reservoir surrounded by an ethylene vinyl acetate membrane that controls the release rate, is an example of a membrane control system. The system provides a weekly zero-order pilocarpine delivery at 20-40 micrograms per hour following the first burst. Ocusert is well tolerated in adults, has few side effects, and provides satisfactory intraocular pressure control. However, it is less tolerable in geriatrics, which has the highest need for treatment.

Medications can be taken in a variety of ways-by swallowing, by inhalation, by absorption through the skin, or by injection.Contraception the FDA recently approved the sale of Norplant, a subcutaneous implant for long-term release of levonorgestrel (a contraceptive). The device consists of six silicon membrane capsules, each containing 36 micrograms of levonorgestrel, placed on the inner surface of the upper or forearm via a trocar, creating a single trocar entry point. These capsules release 70 micrograms per day for the first 100 days and steadily decrease to 30 micrograms per day after about 800 days, with this release rate continuing for 5 years. Other polymer-based systems being studied for contraception include a silicone rubber vaginal ring that is used for 3 to 6 months with a monthly removal period of 1 week during menstruation.

progestasert is an intrauterine device of ethylene vinyl acetate copolymer that can be injected for at least 1 year and contains a suspension of injectable microspheres or rods made of biodegradable polymer. Dental Applications Polymer implants are valued in many dental applications, including long-term topical administration of fluoride antibacterial agents and antibiotics. Stannous fluoride is incorporated into various dental cements to supply sustained release of fluoride. Different hydrogels dispersed in hydroxyethyl methacrylate and methyl methacrylate copolymer hydrogels are coated with an outer layer of the same copolymer in different proportions to be the rate-determining factor for drug release. Approximately 8 mm long, a device containing 42 mg of fluoride in the core was attached to the buccal surface of the maxillary first molar and designed to release 0.5 mg of fluoride per day for 30 days.

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