Nano Toxicity of Nano particles

Nano toxicity has become of increasing concern since the rapid development of metal nanoparticles (NPs). Aquatic nano toxicity depends on crucial qualitative and quantitative properties of nanomaterials that induce adverse effects on subcellular, tissue, and, organ level. The dose-response effects of size-dependent metal NPs, however, are not well investigated in aquatic organisms. In order to determine the uptake and elimination rate constants for metal NPs in the metabolically active/detoxified pool of tissues, a one-compartmental toxic kinetic model can be applied when subcellular partitioning of metal NPs data would be available. The present review is an attempt to describe the Nano-characteristics of toxic kinetics and subcellular partitioning on aquatic organisms with the help of the mechanistic modelling for NP size-dependent physiochemical properties and parameters. Physiologically-based pharmacokinetic (PBPK) models can provide an effective tool to estimate the time course of NP accumulation in target organs and is useful in quantitative risk assessments. NP accumulation in fish should take into account different effects of different NP sizes to better understand tissue accumulative capacities and dynamics. The size-dependent NP partition coefficient is a crucial parameter that influences tissue accumulation levels in PBPK modelling.

Regards

Alex John
Editorial Assistant
Clinical Toxicology