Pain Medications include over the medication drugs that you can buy without a doctor’s prescription. Non-steroidal anti-inflammatory drugs are drugs that help reduce inflammation, which often helps to relieve pain. In other words, they’re anti-inflammatory drugs. NSAID can be very effective. Read on for this information as well as tips on how to use NSAID safely and effectively. NSAID work by blocking prostaglandins, which are substances that sensitize your nerve endings and enhance pain during inflammation