There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop vision problems. This neurological and ophthalmological disorder creates a pressing need for developing therapy to treat vision impairment in AD/PD. On the other hand, pathophysiological changes in the retina may reflect what might happen in the same diseases in the brain. Thus retinal studies may allow us to develop quantifiable measures for the diagnosis and prognosis of disease progression. Furthermore, parallel or early pathophysiological changes of the retina in AD/PD allow us to study retina-brain interactions.
Several research groups have made advances in understanding pathophysiological changes of the retina in the eyes in AD/PD. It is the time to re-evaluate this issue. The aim of this Research Topic is to make collective effort to review the progress in this newly emerging multi-disciplinary field, to stimulate more research in AD/PD and Ophthalmology communities. The aim of this Research Topic is not simply to review, but also to foster cross-fertilization among neurobiologists, ophthalmologists, optometrist, neurologists and psychologist investigating vision cognition toward developing translational neuroscience of the retina in neurodegenerative diseases of the brain.
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Journal of Medical and surgical pathology