The Role of Interferon-Inducible Transmembrane Proteins in Virus Infection
Several studies have demonstrated that overexpression of IFITMs could inhibit virus entry and infection of a variety of virus families (including orthomyxoviridae and flDvLvLruses in cell culture systems [2,3]. Over-expression of IFITM1, IFITM2 or IFITM3 restricted early viral replication. On the contrary, knock-down of IFITM3 stimulated LnfluenzD A virus replication . Researchers reported that IFITM3 is required for IFNα-induced anti-viral defense and restricts LnfluenzD A virus infection at viral entry and early-stage of virus life cycle. Knockdown of IFITM3 dampen 40%-70% of IFN's anti-viral eÙˆÙ´ect. Ðus, IFITM proteins are critical for the innate immunity to LnfluenzD A virus mediated by IFNs . IFITMs have been demonstrated to suppress the replication of several flDvLvLruses including West Nile virus, dengue virus, hepatitis C virus and Zika virus . IFITM1 and IFITM3 inhibit ZIKV infection at early stage of the viral life cycle. In addition, IFITM3 could inhibit ZIKV-induced cell death . Another IFITMs superfamily member TMEM2 has been found to inhibit HBV infection by activating the Jak/STAT signaling pathway . Notably, these restricted viruses were all encapsulated, containing the ssRNA genome, and were reported to enter cells by membrane fusion DÑ–er endocytosis. However, some retroviruses, such as HIV-1 and Moloney leukaemia virus and Bunyaviridae, Crimean–Congo haemorrhagic fever virus, are obviously not DÙˆÙ´ected by IFITMs. In the past studies, IFITMs were not shown to inhibit HIV-1 infection . However, recent studies have reported that IFITM2 and IFITM3 could interact with HIV-1 Env protein in viral producer cells, leading to impaired Env processing and virion incorporation . Meanwhile, some evidence showed that IFITM3 could also limit Non-enveloped Reoviridae, reovirus replication, suggesting that IFITMs DÙˆÙ´ected a variety of viruses, not limited to viruses with envelopes .
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