Archaellum

Image Archaellum An archaellum (plural: archaella, formerly archaeal flagellum) is a unique whip-like structure on the cell surface of many archaea. The name was proposed in 2012 following studies that showed it to be evolutionarily and structurally different from the bacterial and eukaryotic flagella. The archaellum is functionally the same – it can be rotated and is used to swim... Read More

Stay Active and Healthy

Image Running or strolling alone has commonly not been prohibited; however you absolutely should stay away from others and remain inside in the event that you are wiped out or abnormally powerless. On the off chance that you have a home with steps, consider putting things you use normally on various floor to drive you to stroll all over all the time. Floor works out (sit-ups, push-ups and so forth.) are something that require no hardware, just self discipline. A great deal of activity recordings on spilling stages have supplanted bunch exercises and can be followed at home. Track your activity in... Read More

Autoimmunity and constant provocative conditions

Image There are an assortment of reasons somebody may have an undermined resistant framework. This is what we know. As expressed over, specific medications used to treat autoimmunity and constant provocative conditions can bargain the invulnerable framework. There are additionally sicknesses like HIV and inalienable immunodeficiencies (normal variable immunodeficiency, serious consolidated immunodeficiency) that can seriously bargain the invulnerable framework. Ordinary malignant growth chemotherapy and radiation seriously hinder the resistant framework, particularly on the off chance t... Read More

Technical Strategies and advancements in Vaccines & Immune Disorders

Image Vaccines and Immunization When a Vaccine is injected into the body is called as Vaccination. The reaction of the body after administration of vaccine is Immunization. The vaccine stimulates the immune system, recognizes the diseases, protects the body from infection and prevents the spread of diseases to others. Actually, the Vaccination and Immuni... Read More

Cognizance into Unexplored Areas of Paediatrics

Image Paediatrics Paediatrics is the field of medicine that is concerned about the well-being of neonatal, children, and adults. It also concerns on their development and advancement and their chance to accomplish maximum capacity as grown-ups. The Pediatric academy of America, prescribes that the children should be under paediatric care, up to the age of 21. The point of investigation of pediatrics is to decline the death rate of children and newborns, to contr... Read More

Xenobiotic

Image Xenobiotic A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism. It can also cover substances that are present in much higher concentrations than are usual. Also called as detoxification. Natural compounds can also become xenobiotics if they are taken up by another organism, such as the... Read More

Progress in Magnetic Resonance Thoracic Ductography in Interventional Radiology Journal

Image The thoracic duct (TD), as the largest lymphatic vessel, drains approximately three quarters of the body’s lymph into the venous system. In general, the thoracic duct derives from retroperitoneal cisterna chyli, ascends along the spine, and terminates in the venous angle, the region of the junction of the internal jugular vein and the subclavian vein. The cisterna chyli, as a conduit for the lipid products of digestion by receiving fatty chyle from th... Read More

MEDICAL DEVICE TRIALS (JCTR)

Image   Medical Device: World Health Organization defines a Medical Device as, “any instrument, apparatus, implement, machine, appliance, implant, in-vitro reagent or calibrator, software, material or other similar or related article, intended by the manufacturer to be used, alone or in combination, for human beings for one or more of the specific purposes of: Diagnosis, prevention, monitoring, treatment. Classification of Medical Devices By definition, a medical device is any “article, instrument, apparatu... Read More

New Immunoassays of Bioactive TSH Improve Detection of Thyroid Disorders

Image Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Hypothyroidis... Read More

Current eye research: Ophthalmology

Image Eyes are organs of the visual system. They provide animals with vision, the ability to receive and process visual detail, as well as enabling several photo response functions that are independent of vision. Eyes detect light and convert it into electro-chemical impulses in neurons. In higher organisms, the eye is a complex optical system which collects light from the surrounding environment, regulates its intensity through a diaphragm, focuses it through an adjustable assembly of lenses to form an image, converts this image into a set of electrical signals, and transmits these signals to th... Read More

An artificial liquid retinal prosthesis

Image Retinal detachment describes an emergency situation in which a thin layer of tissue (the retina) at the back of the eye pulls away from its normal position. Retinal detachment separates the retinal cells from the layer of blood vessels that provides oxygen and nourishment. The longer retinal detachment goes untreated, the greater your risk of permanent vision loss in the affected eye. Warning signs of retinal detachment may include one or all of the following: the sudden appearance of floaters and flashes and reduced vision. Contacting an eye specialist (ophthalmologist)... Read More

Taxus baccata Leaves Poisoning: Clinical Toxicology

Image Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.[1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). By extension, the word may be metaphorically used to describe toxic effects on larger and more complex groups, such as the family unit or society at large. Sometimes the word is more or less synonymous with poisoning in everyday usage. A ce... Read More

Clinical Toxicology: Updates

Image Clinical Toxicology publishes peer-reviewed scientific research and clinical advances in clinical toxicology. The journal reflects the professional concerns and best scientific judgment of its sponsors, the American Academy of Clinical Toxicology Clinical Toxicology aims to be the journal of primary interest to practicing clinical toxicologists, whether in hospitals, poison centers, academia, government or industry. The journal is relevant to all professionals at the interface of clinical toxicology with acute care, occupational and environmental medicine, public health, regulator... Read More

COVID-19 and Anesthesiologists

Image The coronavirus disease 2019 (COVID-19) has spread at unprecedented speed all over the world. The first outbreak of COVID-19 was in Wuhan, China, where Chinese anesthesiologists had to encounter increasing numbers of infected patients since December 2019. The first case of COVID-19 was reported in early December 2019 in and it was called as pneumonia. Approximately 15 to 20% of patients with COVID-19 required some form of oxygen therapy and ventilation support. Anesthesiologists who are responsible for airway management are at enhanced risk, if not the highest risk, of contamination. ... Read More

Chrysemys picta: Painted Turtle

Image Painted turtles are medium-sized turtles with a shell length of 4 to 10 inches. Females tend to be larger than males, but males have longer foreclaws and longer thicker tails than females do. As suggested by their name, painted turtles are ornately coloured throughout their body; they have black to olive skin with red and yellow stripes. Their lower shells are mostly yellow with varying shapes and sizes of other co... Read More

Ambystoma gracile: An overview

Image They are large, with a short round head and large paratoid glands behind eyes and have a thick glandular region on the upper part of their tail and ridged lines along the sides of their body. They look like dark brown, gray or black; sometimes have flecks of cream or yellow and almost 7-13 cm. The Northwestern salamander is restricted to the Pacific coast of North America. In Washington State they are found west of the cascades, includin... Read More

Bimodal copper oxide nanoparticles doped phase

Image Bimodal copper oxide nanoparticles doped phase Polymers obtained from tetraethyl orthosilicate (TEOS) and triethoxymethylsilane (MTEOS) have been functionalized with different metal and metal oxide nanoparticles (NPs), and used as coatings of extractive capillaries for the extraction of polar compounds by in-tube solid-phase microextraction (IT-SPME) coupled on-line to nano-liquid chromatography (nano-LC). The extraction capabilities of the new phases have been studied using several triazinic herbicides with log of octanol/water partition coefficients (Kow) ranging from... Read More

Effect of Hydroxychloroquine on CORONA-19

Image Effect of Hydroxychloroquine on CORONA-19 Hydroxychloroquine is utilized to forestall or treat jungle fever brought about by mosquito nibbles. The United States Center for Disease Control gives refreshed rules and travel suggestions for the counteraction and treatment of intestinal sickness in various pieces of the world. Talk about the latest data with specialist before making a trip to zones where intestinal sickness happens. This medicine is additionally used to treat certain auto-invulnerable ailments (lupus, rheumatoid joint pain). It has a place wi... Read More

CHOROID (jedd)

Image Definition: The choroid is the vascular layer of the eye that lies between the retina and the sclera. The choroid is thickest in the back of the eye at about 0.2 mm and narrows to 0.1 mm in the peripheral part of the eye. It contains the retinal pigmented epithelial cells and provides oxygen and nourishment to the outer retina. The choroid forms the uveal tract which includes the iris and the ciliary body. Layers The choroid is made of four different layers: Haller's layer (large blood vessel lay... Read More

Clinical trials on covid-19 (jctr)

Image Definition: COVID-19 is a disease caused by a new strain of coronavirus. 'CO' stands for corona, 'VI' for virus, and 'D' for disease. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment.  Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely... Read More

Covid-19 effect on autoimmune diseases

Image Alongside the raised hazard for coronavirus infection 2019 (COVID-19)- related difficulties in patients with hidden ailments, for example, diabetes and cardiovascular sickness, people with immune system illnesses may likewise confront a few dangers identified with their condition and the idea of their treatment. Specialists assessed the dangers and advantages of proceeding with upkeep immunosuppression for patients contaminated with or in danger of contracting serious intense respiratory disorder coronavirus 2 (SARS-CoV-2). While treatment choices ought to at last be resolved in a... Read More

Hyperthyroidism (over Active Thyroid)

Image Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Hyperthyroidism (overactive thyroid) occurs when your thyroid gland produces too much of the hormone thyroxine.... Read More

Clinical Toxicology: Its description

Image Journal of Clinical Toxicology offers academic, industry, and regulatory toxicologists, as well as toxicology consultants, timely, peer-reviewed, multidisciplinary articles and incisive reviews on contemporary issues in toxicology, plus safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. Each issue of Journal of Clinical Toxicology provides an important forum for articles that promote basic toxicology research, as well as those that facilitate and improve toxicology practice. We are currently seeking manuscript su... Read More

A Case of a Suicide Attempt by Taxus baccata Leaves Poisoning

Image Journal of Clinical Toxicology publishes papers in all areas of toxicological sciences, including the structure, function, and mechanism of agents toxic to humans and/or animals, as well as toxicological medicine, safety evaluation, and environmental health. Journal of Clinical Toxicology offers academic, industry, and regulatory toxicologists, as well as toxicology consultants, timely, peer-reviewed, multidisciplinary articles and incisive reviews on contemporary issues in toxicology, plus safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biom... Read More

Need and Time to Redo Selective Laser Trabeculoplasty in Glaucoma Patients

Image Journal of Clinical and Experimental Ophthalmology is a journal which provides rapid peer-review process with 6 issues per year (Bi Monthly). Journal of Clinical and Experimental Ophthalmology accepts all types of articles including case-reports, research, review, case-series, mini-review, opinion articles, short communications, commentary, perspective and video articles. Journal of Clinical and Experimental Ophthalmology has recently release its 3rd issue in 2020 with 6 articles and 3 Research articles, 2 case reports and a short communication. Here we are mentioning about the ca... Read More

Comparison of Three Intraocular Lens Calculation Formulas

Image Journal of Clinical and Experimental Ophthalmology is a journal which provides rapid peer-review process with 6 issues per year (Bi Monthly). Journal of Clinical and Experimental Ophthalmology accepts all types of articles including case-reports, research, review, case-series, mini-review, opinion articles, short communications, commentary, perspective and video articles. Journal of Clinical and Experimental Ophthalmology has recently release its 3rd issue in 2020 with 6 articles and 3 Research articles, 2 case reports and a short communication. Here we are mentioning about the ca... Read More

Innovations in Automation and Artificial Intelligence

Image Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of increasing smart software and systems. In the real life, the knowledge has some undesirable properties. AI is different from ... Read More

Identification of pre-operative, intra-operative and post-operative risk factors for aspiration pneumonia in patients undergoing abdominal surgery

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine brings articles in all areas related to Chronic diseases on biannually basis. Acute and Chronic Disease Reports welcomes the submission of manuscripts that meet the general criteria of significance and scien... Read More

γδ T cells

Image γδ T cells Gammadelta T-cells (γδT cells) were originally discovered as a result of a search for the significance of a rearranging T cell receptor (TCR) gene, γ, which did not appear to be expressed at the protein level in CD4+ or CD8+ αβTCR+ T cells. In one of two first papers that unveiled these cells, it was noted that triggering the γδTCR with an antibody to CD3 induced potent in vitro cytotoxicity against leukemic cells. Since then, accumulating studies have demonstrated that γδT cells play a cr... Read More

Academic Anesthesiologists Perceive Significant Internal Barriers to Intraoperative Teaching in a Cross-Sectional Survey

Image Journal of Perioperative Medicine is an international, peer reviewed journal with a multidisciplinary ethos across all aspects of perioperative care. The overall aim of the journal is to improve patient safety through informing and developing practice. Journal of Perioperative Medicine is an informative professional journal which provides current evid... Read More

Dual-target kinase drug design

Image Drug Designing: Open Access is a peer-reviewed and open access journal with an aim to provide rapid and reliable source of information in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. Protein kinases are well-known to orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to cont... Read More

Data collectors perspectives and practices of bioethics

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Fertility Preservation

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Human Embryonic Stem Cells (hESC)

Image Human embryonic stem cells (hESCs) require a supportive niche consisting of appropriate cues and signals. These niches can maintain hESCs in an undifferentiated state or promote their differentiation into specific phenotypes, depending on their properties. Biomaterial scaffolds can be engineered to provide such regulatory cues and thereby support and control these important cell functions. This updated chapter de... Read More

Personalized Medicine and Epigenetic Drug Development

Image Epigenetic modifications have had an important function in the evaluation of potential biomarkers for patient cancer diagnostics . The goals have been to identify patient populations likely to respond to specific anticancer therapies and to define reasonable dosages for investigational anticancer drugs. The profiles of genetic and epigenetic alterations were characterize... Read More

Neuroendocrinology-Assisted reproductive technologies

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

In vitro fertilization (IVF)

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Offspring born to women with PCOS

Image Disturbances during intrauterine life have been implicated in the origin of PCOS and may modify the endocrine and metabolic function of a child born to a PCOS mother independently of genetic inheritance and sex. Daughters of women with PCOS show 4 components of the syndrome (ovarian dysfunction, neuroendocrine dysfunction, hyperandrogenism, and hyperinsulinemia) that appear in a sequential pattern during infancy, childhood and puberty increasing the chance for developing PCOS during adulthood. Sons born to PCOS mothers show few reproductive but important metabolic disturbances. These metabo... Read More

Assisted reproductive technology can reverse the “aged biological clock”

Image The fertilization of human oocytes outside of the body, the culturing of the embryo(s) in the laboratory, and the subsequent transfer of embryo(s) to the uterus has resulted in the birth of tens of thousands of children worldwide. Registries in the US and abroad reflect an explosion both in the number of programs offering ART and in the utilization of these technologies since the 1980s. The growth in utilization has led... Read More

posthumous sperm procurement

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Septic joint inflammation

Image Septic joint inflammation, otherwise called joint contamination or irresistible joint inflammation, is the attack of a joint by an irresistible specialist bringing about joint aggravation. Manifestations commonly incorporate redness, warmth and torment in a solitary joint related with a diminished capacity to move the joint. Beginning is normally fast. Different side effects may incorporate fever, shortcoming and cerebral pain. Incidentally, more than one joint might be included. Causes incorporate microscopic organisms, infections, growths and parasites.Risk factors incorporate a... Read More

Autoimmune disease

Image Autoimmune disease An immune system illness is a condition emerging from an anomalous insusceptible reaction to an ordinary body part. There are at any rate 80 sorts of immune system maladies. Almost anyone part can be included. Basic side effects incorporate second rate fever and feeling tired. Frequently side effects travel every which way. The reason is commonly obscure. Some immune system maladies, for example, lupus run in families, and certain cases might be activated by diseases or other natural variables. Some regular infections that are commonly... Read More

CONJUNCTIVA (jedd)

Image Conjunctiva Definition The conjunctiva is the clear, thin membrane that covers part of the front surface of the eye and the inner surface of the eyelids. It has two segments: Bulbar conjunctiva. This portion of the conjunctiva covers the anterior part of the sclera (the "white" of the eye). The bulbar conjunctiva stops at the junction between the sclera and cornea; it does not cover the cornea. Palpebral conjunctiva. This portion covers the inner surface of both the upper and lower eyelids. (Another term for the palpebral conjunctiva is tarsal conjunc... Read More

RANDOMIZED CONTROLLED TRIAL (jctr)

Image Definition The randomised control trial (RCT) is a trial in which subjects are randomly assigned to one of two groups: one (the experimental group) receiving the intervention that is being tested, and the other (the comparison group or control) receiving an alternative (conventional) treatment (fig 1). The two groups are then followed up to see if there are any differences between them in outcome. The results and subsequent analysis of the trial are used to assess the effectiveness of the intervention, which is the extent to which a treatment, procedure, or servic... Read More

Molecular mechanisms of metalloid transport, toxicity and tolerance

Image The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors ... Read More

The Environmental Hazards of Toxic Metals Pollution

Image The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors ... Read More

Food spoilage

Image Food spoilage Food spoilage is the process where a food product becomes unsuitable to ingest by the consumer. The cause of such a process is due to many outside factors as a side-effect of the type of product it is, as well as how the product is packaged and stored. Due to food spoilage, one-third of the world's food produced for the consumption of humans is lost every year. Bacteria and various fungi are the cause of spoilage and can create serious consequences for the consumers, but there are preventive measures that can be ta... Read More

Food grading

Image Food grading Food grading involves the inspection, assessment and sorting of various foods regarding quality, freshness, legal conformity and market value. Food grading often occurs by hand, in which foods are assessed and sorted. Machinery is also used to grade foods, and may involve sorting products by size, shape and quality. For example, machinery can be used to remove spoile... Read More

Eye movement-related brain activity during perceptual and cognitive processing

Image Journal of Clinical and Experimental Ophthalmology considers articles on clinical ophthalmology related issues such as ophthalmia neonatorum, pterygium histology, aphakic glaucoma, acute zonal occult outer retinopathy (AZOOR), hypertrophic pachymeningitis, phacomorphic glaucoma, pseudoexfoliation syndrome, binasal hemianopsia, bitemporal heteronymous hemianopsia, cycloplegic refraction, cycloplegic drugs, macular edema optical coherence tomography (OCT), juxta fovea retinal telangiectasis, central serous retinopathy treatment, involutional ectropion, impaired depth perception, lacrimal fist... Read More

Parkinson's Disease & Alzheimer’s Disease related to eye

Image This Ophthalmology journal focuses on different aspects of eye surgery such as post lasik conditions and care, surgically induced astigmatism, cataract surgery, corneal transplant success rate, paecilomyces infection, clear corneal incision, post-operative corneal melt, malyugin ring cataract surgery are under the scope of the journal. There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop ... Read More

Effect of Protective Cover on the Quality of Life of Patients With Tracheostomy—A Quasi-Experimental Study

Image Journal of Perioperative Medicine seeks original articles useful to nurses interested in all phases of perioperative care in PACUs (Phases 1 and 2), procedural areas, surgery facilities, and critical care units. Readers are experienced clinicians practicing in diverse areas and involved in the care of patients undergoing procedures requiring sedation, analgesia, and anesthesia. ... Read More

Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations

Image Journal of Perioperative Medicine is a peer reviewed, open access periodical that underlines the importance of pre-operative medical care, procedures and protocols in assuring stress free and healthy post-operative life of the patient. Journal of Perioperative Medicine provides a broader platform to discuss a wide range of topics in this field including Local Anesthesia, ... Read More

Immunology and Pathology

Image Immunology and Pathology The prototype of the granulomatous inflammation,-the mycobacterial tubercle,was first described by pathologists over 150 years ago.Granulomas are focal, chronic tissue inflammations in reaction to persistent microbial invaders,as well as chemical irritants.Immune granulomas are generated by CD4+T effector/helper cells.This Research Topic is initiated to provide a specific state-of-the-art forum dedicated only to the various aspects of the granulomatous response.This includes the molecular basis of the initial interaction of the innate and ... Read More

Brain Pathology Research

Image Brain Pathology Research The Transient Receptor Potential (TRP) channels compromise a superfamily of polymodal receptors that are critically involved in the detection of diverse stimuli such as temperature or pH changes, noxious chemicals or mechanical forces. This ability to sense environmental changes is essential for survival, and thus the disruption of TRP channel function can have a severe impact on human health, as evidenced by the increasing number of hereditary and acquired diseases linked to TRP channels. Many members of the TRP channel superfamily are ex... Read More

Dry Eye Treatments and Preference Survey

Image Purpose: To survey ophthalmologists regarding their current therapy preferences and desires for future treatment to help guide providers in choosing treatments and pharmaceutical startups in developing future therapies. Methods: A prospective survey developed internally and sent twice to ophthalmologists. Results: There were 76 responses. Approximately 30% of respondents stated they examined a few cases of dry eye disease (DED) patients a day and 20% noted DED was a majority of their practice. Almost all physicians recommended tear replacement drops (95%) for their patients while 80% prescr... Read More

Pasteurization

Image Pasteurization Pasteurization or pasteurisation is a process in which water and certain packaged and non-packaged foods (such as milk and fruit juice) are treated with mild heat, usually to less than 100 °C (212 °F), to eliminate ... Read More

Design of a Multicenter, Randomized, Open Label, Parallel Group Study to Evaluate the Efficacy of Loxoprofen on Acute-Phase Reactions in Japanese Primary Osteoporosis Patients Treated with Zoledronic Acid (jctr)

Image Treatment of osteoporosis with once-yearly zoledronic acid was approved in September 2016 in Japan. Like other bisphosphonates, zoledronic acid causes acute-phase responses (APRs), which are more severe in Asian populations than in multinational populations. The aim of this multicenter, randomized, open label, parallel group study is to investigate the incidence of APRs in Japanese patients with primary osteoporosis in real clinical settings, and to test the hypotheses that APRs are suppressed by administering one of the most commonly used nonsteroidal anti-inflammatory drugs in Japan, loxo... Read More

Nephropathy

Image Nephropathy Due to its rapidly increasing prevalence, chronic kidney disease (CKD) has become a global health problem. The main causes of CKD include age-related renal function decline, hypertension, diabetes, obesity as well as primary renal disorders. It has been well established that podocytes, the highly differentiated glomerular cells are critical determinants of outcome for all glomerular diseases. The limited ability of mature podocytes to self-renewal is a major cause of progressive kidney diseases, regardless of their diverse origins. Their impairment is ... Read More

Could Concurrent Use of Herbal Medicinal Products and Prescription DrugsRaise Older Adults Risk of Vascular Dementia

Image The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors ... Read More

The Effect of Selenium on Hashimoto’s Thyroiditis: Systemic Review and MetaAnalysis

Image The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors ... Read More

Spontaneous generation

Image Spontaneous generation Spontaneous generation refers to an obsolete body of thought on the ordinary formation of living organisms without descent from similar organisms. The theory of spontaneous generation held that living creatures could arise from nonliving matter and that such processes were commonplace and regular. For instance, it was hypothesized that certain forms such as fleas could arise from inanimate matter such as dust, or that maggots could arise from de... Read More

Experience against COVID-19 Pandemic in Ophthalmology

Image Journal of Clinical and Experimental Ophthalmology is a journal which provides rapid peer-review process with 6 issues per year (Bi Monthly). Journal of Clinical and Experimental Ophthalmology accepts all types of articles including case-reports, research, review, case-series, mini-review, opinion articles, short communications, commentary, perspective and video articles. Journal of Clinical and Experimental Ophthalmology has recently release its 3rd issue in 2020 with 6 articles and 3 Research articles, 2 case reports and a short communication. Here we are mentioning a... Read More

Adverse Drug Reactions

Image Adverse Drug Reactions Adverse reactions to therapeutic drugs represent a significant problem for patient care. Whilst most reactions can be explained by the drug pharmacology and are termed “predictable”, a subset of reactions are “idiosyncratic”, often mediated by inappropriate activation of the immune system. These reactions complicate the use of a wide range of therapeutics including anti-epileptic drugs (e.g. carbamazepine, phenytoin), antimicrobials (e.g. penicillins, sulphonamides, tuberculosis therapies), antivirals (e.g. abacavir, ... Read More

Immuno-Oncological Mechanism of Cancer

Image Immuno-Oncological Mechanism of Cancer Many chronic complex diseases such as cancer, diabetes, and asthma are being redefined as heterogeneous and the deregulation of the immune system is at the heart of many of these diseases. Due to the complexity of the immune system, it has become evident that a multidisciplinary approach is essential for gaining a thorough understanding of the mechanisms involved in modulating the immune system in various diseases. Systems immunology brings together methodologies and tools from the fields of mathematics, engineering, physics,... Read More

Adult Rhabdomyosarcoma: A Rare Ophthalmic Case Report

Image Journal of Clinical and Experimental Ophthalmology is a journal which provides rapid peer-review process with 6 issues per year (Bi Monthly). Journal of Clinical and Experimental Ophthalmology accepts all types of articles including case-reports, research, review, case-series, mini-review, opinion articles, short communications, commentary, perspective and video articles. Journal of Clinical and Experimental Ophthalmology has recently release its 3rd issue in 2020 with 6 articles and 3 Research articles, 2 case reports and a short communication. Here we are mentioning a... Read More

A Pioneer Model for Nurturing Education in Immunology

Image A Pioneer Model for Nurturing Education in Immunology In 1991 Serafino Zappacosta, Professor of Immunology at the Federico II University of Naples, founded the “Scuola Superiore di Immunologia Ruggero Ceppellini” (defined herein as the Ceppellini School, CS). The school was founded with the aim of fostering education in Immunology at the international level and to attract young scientists to the discipline. The foundation of CS was a major breakthrough in accelerating Immunology education and it rapidly became a powerful attractive pole for the immunol... Read More

Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance

Image Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal... Read More

Raynaud phenomenon or Raynaud marvel

Image Raynaud phenomenon or Raynaud marvel is a manifestation complex brought about by hindered advanced perfusion and can happen as an essential wonder or optional to a wide scope of basic causes. Raynaud marvel happens in practically all patients with fundamental sclerosis (SSc) and is regularly the most punctual clinical indication to happen. Cautious appraisal is required in patients with Raynaud marvel to abstain from missing optional causes, for example, SSc. Advanced ulcers are an agonizing and handicapping noticeable indication of computerized vascular injury in patients with SSc. Progres... Read More

Systemic sclerosis/Foundational sclerosis

Image Systemic sclerosis/Foundational sclerosis is a complex immune system ailment portrayed by an interminable and much of the time dynamic course and by broad patient-to-tolerant changeability. Like other immune system maladies, fundamental sclerosis happens all the more regularly in ladies, with a pinnacle of beginning in the fifth decade of life. The specific reason for fundamental sclerosis stays subtle yet is probably going to include natural factors in a hereditarily prepared person. Pathogenesis is commanded by vascular changes; proof of autoimmunity with particular autoantibodies and ena... Read More

Metastatic Papillary Thyroid Cancer with no Primary Tumor in the Thyroid Gland

Image Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Papillary-type ... Read More

Randomized Comparison of Monitored Anesthesia Care and General Anesthesia Techniques in Patients Undergoing Sialendoscopies

Image Journal of Perioperative Medicine is an Open Access peer reviewed, online publishing journal which aims to publish scholarly and quality papers in the significant areas of anesthesia research. Anesthesia will select the doses of one or more drugs to achieve the types and degree of anesthesia characteristics appropriate for the type of procedure and it is an instant sedation or awareness through an Intravenous line to the particular patient. Anesthesia is a thin p... Read More

The human eye is 'susceptible' to coronavirus infection, new study warns

Image The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology. The acceptance criteria for all papers are the quality, originality and significance of the research. Manuscripts are peer reviewed in an average time of 6 weeks, and accepted manuscripts are published online in an average of 7 days from receipt a... Read More

Biomimetic Self-Organization and Self-Healing

Image Swarm intelligence refers to collective intelligence. Biologists and natural scientist have been studying the behavior of social insects due to their efficiency of solving complex problems such as finding the shortest path between their nest and food source or organizing their nests. In spite of the fact that these insects are unsophisticated individually, they make wonders as a swarm by interaction with each other and their ... Read More

“New Era of Scientific Insight in the Prevention & Treatment of Viral Diseases”

Image Vaccines Vaccines play a crucial capacity in keeping us solid. They watch us from basic and sometimes savage infections like Haemophilus flu type b (HIb) and measles. It's far created from exceptionally limited quantities of feeble or dead germs which could reason diseases for example, infections, microscopic organisms, or toxins. It readies your edge to battle the ailment speedier and extra successfully so you won't get unwell. Undertaking in ... Read More

Human Vaccines - Infectious & Non Infectious Diseases

Image A vaccine is an inactivated form of bacteria or virus that is injected into the body to simulate an actual infection. Because the injected microorganisms are 'dead,' they don't cause a person to become sick. Instead, vaccines stimulate an immune response by the body that will fight off that type of illness. It covers infectious disease targets and non-infectious disease targets. To generate vaccine-mediated protection is a complex challenge. Currently available vaccines ... Read More

Is Goiter is an Endemic Problem | Thyroidectomy

Image Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive. Extent of th... Read More

The truth of social insurance in 2020 is that advancements that can positively affect understanding consideration aren't in every case promptly accessible to the individuals who might profit the most

Image Take for instance osteoporosis, where practically 50% of patients who endure an osteoporotic hip break have encountered a past osteoporotic crack, yet the majority of these patients didn't get treatment that would have decreased the danger of hip crack after that underlying break. The admonition sign (the underlying crack) was there however not followed up on, thus they didn't gain admittance to the treatment or administrations that could have diminished their danger of a subsequent break. A year ago, a strategy brief composed for the World Health Organization (WHO) focused on this ... Read More

Osteoporosis, delicacy breaks and the critical requirement for prioritization of care

Image Osteoporosis is the world's most normal bone malady; influencing around 200 million individuals universally, it brings about more than 8.9 million delicacy cracks every year, with around one out of three ladies and one of every five men beyond 50 a years old a delicacy break in the course of their life. In any case, with more individuals living longer, is sufficient being done to guarantee those in danger of delicacy breaks are being recognized and enough overseen so they can appreciate satisfying later lives? Individuals are living longer and, properly, hoping for something e... Read More

Epidemic Disease

Image Epidemic Disease An epidemic (from Greek ἐπί epi "upon or above" and δῆμος demos "people") is the rapid spread of disease to a large number of people in a given population within a short period of time. For example, in ... Read More

Trachoma Elimination (JEDD)

Image Trachoma is caused by conjunctival infection with a Bacteria, Chlamydia trachomatis. According to WHO grading system trachomatous trichiasis (TT), leads to irreversible blindness. Amhara national state of Ethiopia has the highest burden of TT. Despite huge efforts the region has big backlog and far from the target. We carried out a review and trend analysis on previous years of Trachoma intervention in the region. We also designed a logical frame work, which bring all actors together. Then the new approach of TT surgery intervention frame work ''The MUST" was implemented. The r... Read More

Inhibitory Effect of Calcium Alginate on Postprandial Blood Glucose Elevation (JCTR)

Image   Diabetes is known to increase the risk of myocardial and cerebral infarction, as well as complications such as retinopathy, nephropathy and neuropathy. It is important for diabetics to improve their eating habits, for example, by eating slowly, avoiding overeating, and increasing their intake of vegetables, in order to suppress sudden rises in blood glucose (Glu) levels. On the other hand, alginic acid (Alg), which is a polysaccharide derived from brown algae, is used as a food and medicinal additive, a health food and a pharmaceutical, based on its blood cholesterol-loweri... Read More

Pediatric Polycystic Kidney Diseases

Image Pediatric Polycystic Kidney Diseases Autosomal Recessive Polycystic Kidney Disease (ARPKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) are both inherited cystic kidney diseases that can span the age spectrum from prenatal presentation to diagnosis in late adolescence and adulthood. ARPKD is characterized by polycystic kidneys and the liver lesion, congenital hepatic fibrosis, and is caused by mutations in the gene, PKHD1. Most affected patients present in the prenatal period with enlarged echogenic kidneys with or without oligohydramnios and mortality... Read More

Malaria Parasite in the Liver

Image Malaria Parasite in the Liver Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A... Read More

Acute liver injury

Image Acute liver injury Acute liver injury is a rather rare but often fatal condition. While the mechanisms leading to liver injury for certain etiologies (drug induced liver injury, acetaminophen poisoning) have been elucidated in detail, it remains unclear, what causes a fatal course in many types of liver damage. Similarly, little is known about the mechanisms that account for the diversity of clinical outcomes in acute liver failure, which range from spontaneous recovery to death or the need for orthotopic liver transplantation. Contribution of different hepatocyte... Read More

Prioritisation of quality indicators for elective perioperative care

Image Perioperative Medicine is an open access journal that publishes highly topical clinical research relating to the perioperative care of surgical patients. Its essence is the distillation, examination and application of clinical evidence to improve surgical outcome. Modern perioperative medicine is a true multidisciplinary speciality and the journal welcomes research in all areas relevant to perioperative medicine from any healthcare professional. EBPOM is a not for profit collaborative project between a number of UK and international academic institutions that exists to promote the... Read More

Existential Philosophy in Medicine

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Epidemiologic findings on the effect of metabolic syndrome (MetS)

Image Abstract Background. Epidemiologic findings on the effect of metabolic syndrome (MetS) and its treatment on colorectal cancer (CRC) survival have been inconsistent and have not been previously studied in an Arab population such as the Omani population. Patients and Methods. Data from the hospital records of 301 CRC patients treated in Sultan Qaboos University (SQUH), Oman, from 2006 to 2014 were analyzed retrospectively to determine the effects of MetS and its treatment on CRC survival. Overall survival (OS) by MetS status and by medicatio... Read More

Adoptive Lymphocyte Immunotherapy

Image Background:  For a long time, phenomenon of defective immune-surveillance in cancer patients from pathological standpoint was not elucidated. I have reported 1985 that lowering seral cyclic AMP is biochemical reason of defective immunesurveillance from adoptive lymphocyte immunotherapy experiment among cancer patients. Recently, Honjo Tasku et al., reported why T cell don’t attack cancer c... Read More

Latest Research paper on Astrobiology

Image honour and privilege to inform you that, our journal running 5th volume by welcoming Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Astrobiology & Outreach. The Journal of Astrobiology & Outreach aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Astrobiology. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals as well as organizes more... Read More

Ologen versus Mitomycin-C for Trabeculectomy (jedd)

Image To investigate the efficacy and safety of the collagen-based Ologen implant as an adjuvant therapy in trabeculectomy as compared to mitomycin-C (MMC) in a predominantly African American patient population. Methods: This study was a retrospective review of 54 eyes of 50 primary open angle glaucoma patients who underwent trabeculectomy with either MMC or Ologen. 16 eyes were included in the MMC group and 38 in the Ologen group. Primary outcomes included treatment success (as defined by target IOP <21 mmHg, IOP reduction >20) both qualified (with and without medications) and unqualified ... Read More

Epidemio-Clinical Profile of the Symbpharon during Toxic Epidermal Necrolysis (TEN) at the Institute of African Tropical Ophthalmology

Image Toxic epidermal necrosis (TEN) is an acute necrosis of the epidermis exceeding 30% of the body area, usually of druginduced toxic origin and in the presence of several cofactors [1]. It is a dermatological emergency because it involves short-term life prognosis [2]. When its evolution is favourable, the healing takes place within two weeks but leaves the most often serious sequelae affecting especially the mucous membranes (including oculars) [3]. The most serious and disabling ophthalmological sequel is the symbpharon, which is the adhesion of the two conjunctives (palpebra and bulba) [3].... Read More

HIV Associated Eye Diseases: Existing Cognitive and Possible Mechanisms

Image HIV-1-related eye diseases have become a great challenge for patients of HAART treatment all over the world. Approximately 70% of HIV-1 infected patients acquire ocular opportunistic infections and manifest eye disorders during the course of their illness [1]. A single-center, retrospective study in Tokyo, of the 1,515 study patients, HIV retinopathy (HIV-R) was diagnosed in 127 (8%) patients [2]. Severe retinopathy and uveitis are the main unon treatable causes of ablepsia in these patients, since the molecular mechanism has remained unclear until now. In this Review, we present an overvie... Read More

Phase I Clinical Trial with a Novel Altered Peptide Ligand Derived from Human Heat-Shock Protein 60 for Treatment of Rheumatoid Arthritis:

Image CIGB 814 is an Altered Peptide Ligand (APL) from a CD4+ T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. This clinical trial was conducted to assess safety and pharmacokinetics (PK) of CIGB-814 in patients with RA. 20 patients with moderated active RA were included in an open label trial. Sequential dose-escalation of 1, 2.5 and 5 mg of CIGB-814 was studied. Consecutive groups of six, five and nine patients receive... Read More

A Mimicker of Yellow Oleander Poisoning producing toxicity

Image In the emergency department, the combination of gastrointestinal symptoms with heart block should make one suspect poisoning due to cardiac glycosides. Here we report a case of poisoning due to Cryptostegia grandiflora which also contains cardiac glycosides. Toxicity of Cryptostegia grandiflora is known among animals. However, very few case reports are available on the human toxicity of Cryptostegia grandiflora worldwide. A 45-year-old male presented to the emergency department with recurrent episodes of vomiting of one day duration. He had ingested a paste made up of leaves of a ... Read More

HIP AND KNEE REVISIONS: USAGE OF CERAMENT

Image HIP AND KNEE REVISIONS: USAGE OF CERAMENT is a surgery performed by an orthopedic specialist that adjusts or totally replaces a joint in the body, generally to reestablish ordinary movement and diminish torment in a contorted or unhealthy joint, for example, the hip, knee, shoulder, elbow or lower leg. Arthroplasty may likewise be required because of ligament that wears out, appendage/joint malalignment, joint space narrowing, a solid joint, sickness, or other degenerative or horrible conditions. Contingent upon the seriousness of the issue with the joint and different variables, ... Read More

CERAMENT™|BONE VOID FILLER

Image CERAMENT™|BONE VOID FILLER is an injectable and flexible artistic bone substitute proposed for bone voids. The material comprises of a powder and a fluid segment. The significant constituents of the powder are hydroxyapatite and calcium sulfate hemihydrate. The fluid segment contains iohexol (C-TRU) as a radio-opacification enhancer. Blending the parts, with the consolidated blending infusion gadget (CMI), brings about a gooey material expected to set ex-vivo or in-vivo. By joining hydroxyapatite and calcium sulfate an ideal equalization is accomplished between embed resorption rate a... Read More

Graves’ Orbitopathy

Image Graves’ Orbitopathy Graves' orbitopathy (GO) is characterized by inflammation of orbital connective tissues that develops in around 25-70% of patients with Graves' disease (GD). As the most common extrathyroidal manifestation of GD, the annual incidence of GO is three cases per 100,000 males and 16 cases per 100,000 females. GO has puzzled generations of clinicians and scientists because of its diverse clinical manifestations, obscure pathogenesis, and the challenges posed by its management. Typically, the natural history of GO includes an active, in... Read More

Immunomodulatory

Image Immunomodulatory Human protozoan infections are an important target for development of new vaccines and drugs. No completely efficacious vaccines for human protozoan infections are available and in the case of malaria resistance to the most efficacious antimalarials has become a global challenge. In ocular toxoplasmosis complete eradication of the body is not possible, exposing patients to new reactivations. The need of treatment or vaccines for Cryptosporidium and of less toxic drugs for Leishmania are urgent tasks for protozoologists research comm... Read More

Immunotherapeutics

Image Immunotherapeutics The complement system is one of the major constituents of innate immunity, capable not only of killing microbes but also to perform opsonization and guidance of adaptive immunity as well as to scavenge cellular debris, thus limiting the risk of autoimmune events. For a long time the complement was considered a scientifically interesting system with limited physiological relevance. Such view dramatically changed during the last thirty years as direct or indirect involvement of the complement system has been reported in most human diseases. Practi... Read More

Use of an Amphoteric Solution in Eye, Skin and Oral Chemical Exposures

Image A polyvalent amphoteric flushing fluid (Diphoterine® solution) has been utilized for a number of years for decontamination of eye and skin chemical splashes, mainly in industrial settings. Application of this flushing fluid as soon as possible aіer the chemical splash at the accident site can prevent or limit the consequences. Recently, a number of emergency departments have begun using this amphoteric flushing fluid in either the pre-hospital or hospital settings (use by the mobile emergency and intensive care services(SMUR) or in accident and emergency departments). In these circumst... Read More

Utilization of against malarials to handle COVID-19

Image Use of hostile to malarial medications chloroquine (CQ) and hydroxychloroquine (HCQ) to the treatment of COVID-19 ought to be bolstered by a fitting proof base quite far in this difficult situation introduced by the present crisis, and to accordingly offer the greatest advantage conceivable. Considering their in-vitro impact and early clinical outcomes, against malarial medications CQ and HCQ have been proposed to patients with COVID-19 – related pneumonia and are presently remembered for the Chinese rules for the administration of COVID-19. In the edgy quest to di... Read More

HMGB1 in Immunity

Image HMGB1 in Immunity Decades of research have uncovered a variety of molecular mechanisms by which High-mobility group box-1 (HMGB1), also known as HMG1 or Amphoterin, in both immune and non-immune cells, modulate the type and magnitude of immune responses. This ubiquitous, highly conserved protein, HMGB1, was originally discovered in 1973 as a nuclear non-histone protein. The pro-inflammatory activity of extracellular HMGB1 was first discovered as a late mediator of endotoxin lethality in 1999. These findings were explored in the early 2000s in a series of reports e... Read More

The Chemistry, Analysis, and Toxic Effects of Emerging Mycotoxins

Image Mycotoxins are organic compounds of low molecular weight, produced as secondary metabolites by several species of fungi, showing various chemical structures and occurring in agricultural commodities, especially in cereal products. Human and animal diseases caused by mycotoxins are called mycotoxicosis, which are diffuse syndromes due to lesions mainly in organs such as liver, kidneys, epithelial tissue (skin and mucous membranes) and central nervous system, depending on the type of the toxin. Also, mycotoxins may cause mutagenic and carcinogenic effects in several animal models and humans.... Read More

CRISPR/Cas9 Editing and its Use in Eye Development and Disease Study

Image Genetic editing is taking molecular biology by storm, including the fields of development, disease modeling and therapeutics. One of the most popular editing tools, the CRISPR/Cas9 system, is derived from a naturally-occurring bacterial mechanism that defends against invading plasmids and phages. It facilitates precise homing to chromosomal DNA targets of interest, which are then cleaved by cognate nucleases, disrupting the natural DNA sequence. Following DNA cleavage, endogenous repair mechanisms scramble to repair the disrupted chromosome in one of two ways – non-homologous end-join... Read More

Ethology| Animal Ethics

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Hydroxychloroquine use in lupus patients

Image The present flare-up of COVID-19 speaks to a wellspring of worry for the administration of foundational lupus erythematous, SLE, patients. These patients have an expanded danger of extreme contaminations because of their hidden infection, the utilization of immunosuppressive medications, just as the potential nearness of organ harm related with their illness. Hydroxychloroquine, HCQ, a medication that is as of now part of the drawn out consideration treatment for SLE, has been accounted for to have against viral movement in vitro and late distributions have proposed a valuable impact on COV... Read More

Neovascular Age-Related Macular Degeneration

Image Neovascular Age-Related Macular Degeneration (nAMD) is a leading cause of blindness, but the management has been revolutionized by anti-vascular endothelial growth factor (anti-VEGF) agents. Three main treatment strategies have been developed to manage nAMD. The first method is fixed interval dosing, a mainstay of randomized clinical trials (RCT), where patients receive treatments on a monthly or bimonthly interval based on the anti-VEGF agent. Shortly thereafter, the pro-re-nata (PRN) method was introduced, where patients were treated as needed based on OCT status, usually preceded by thre... Read More

Advance Robotic Automation and Swarm Intelligence

Image Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of increasing smart software and systems. In the real life, the knowledge has some undesirable properties. AI is different from ... Read More

Development of vaccines for novel severe acute respiratory disease: (Covid-19)

Image The current threat of avian influenza to the human population, the potential for the re-emergence of severe acute respiratory syndrome (SARS)-associated corona virus, and the identification of multiple novel respiratory viruses underline the need for the event of therapeutic and preventive strategies to combat virus infection. Vaccine development may be a key component withi... Read More

Herpetology: Study of Amphibians and Reptiles

Image Herpetology is a rapidly developing discipline, and while it is a taxonomically restricted field, amphibian and reptile work has set new directions, established new fields, and led to significant discoveries in all fundamental areas of biology—discoveries that have changed the way we think about life on Earth. Herpetology is the study of amphibians and reptiles. Like most other areas of ... Read More

DIABETIC FOOT:USE CERAMENT

Image Foot contaminations and their movement are one of the most well-known and extreme entanglements of diabetes mellitus. In the UK, hospitalization for diabetic patients with foot issue is more noteworthy than all other diabetic complexities consolidated. In the US foot diseases in diabetic patients are the main source of lower-furthest point removals. In Germany, it has been accounted for that 72% of non-horrendous lower-limit removals are owing to diabetes. In most detailed arrangement, about 33% of diabetic patients who present with foot contaminations were found to have proof of ... Read More

TRAUMA: USE CERAMENT

Image Every open crack are sullied by introduction to the outside condition, and the more serious the delicate tissue harm, the more terrible the clinical visualization for disease, wound entanglements, non-association and removal. The goals of careful treatment are to forestall disease, accomplish association and reestablish work. Cracks requiring open decrease interior obsession (ORIF) normally have four principle intricacies: non-association, re-break, embed disappointment and disease. Profound contaminations can't be restored within the sight of equipment, yet evacuating equipme... Read More

Co Morbidity of HIV and Breast Cancer: A One Year Multicentric Pilot Study in Cameroon

Image The burden of disease in developing countries is being overwhelmed by known and emerging infections. It has also been shown by various studies that non-communicable diseases are becoming a public health problem in these communitie. Numerous viral infections have for long been associated with various types of cancers. Prominent amongst these is the cervical cancer . The history of HIV and its link with cancer started with the first descriptions of AIDS [4]. People infected with HIV have a higher risk of some types of cancer than uninfected people. Almost 4 decades after the apparition of the... Read More

Surgical Management of Glaucoma in Sturge-Weber Syndrome

Image Sturge-Weber syndrome (SWS) or encephalo-trigeminal hemangiomatosis is a sporadic, mesodermal phakomatosis characterised by hemangiomas involving many parts of the body, particularly ocular, intracranial and facial cutaneous structures [1-3]. Glaucoma is a common feature, with an incidence of 30%-71% in patients with Sturge-Weber syndrome [4-6]. Many mechanisms of raised intraocular pressure have been described in the past, the most consistent being congenital trabeculodysgenesis, increased episcleral venous pressure and hypersecretion due to ciliary body angioma [7,8]. An increased risk of... Read More

Assessment of the Relationship between Galectine-3 and Cardiac Functions

Image HF biomarkers have growing importance in daily clinical practice as well as in clinical trials. Several biomarkers are used for diagnosis and prognosis of HF patients. Recently, Galectine-3 has been proposed for diagnosis and prognosis of HF. In this study we aimed to determine the relationship between galectine-3 level and cardiac functions in patients with chronic heart failure and its correlation with clinical manifestations. The current study enrolled 90 patients with chronic heart failure and then divided according to ejection fraction (EF) into two groups, group I included 60 patients... Read More

Current Trends in Clinical and Experimental Ophthalmology

Image Historically, cognitive sciences have considered selective attention and working memory as largely separated cognitive functions. That is, selective attention as a concept is typically reserved for the processes that allow for the prioritization of specific sensory input, while working memory entails more central structures for maintaining (and operating on) temporary mental representations. However, over the last decades various observations have been reported that question such sharp distinction. Most importantly, information stored in working memory has been shown to modulate selective a... Read More

Investigation of the Association between the Oral and the Gut Microbiome in Glaucoma

Image Journal of Clinical and Experimental Ophthalmology is an open access peer reviewed journal which publishes articles bi-monthly. Journal provides rapid peer review process. Recently journal has published its 2nd bi-monthly issue of its 11th volume with 6 regular articles and an editorial note.   In its 2nd issue of 11th volume Journal of Clinical and Experimental Ophthalmology has published an article the Investigation of the Association between the Oral and the Gut Microbiome in Glaucoma.   Androge... Read More

Risk Factors for Anal Dysplasia among Privately Insured HIV-Negative Women

Image Risk Factors for Anal Dysplasia among Privately Insured HIV-Negative Women Journal of Cancer Research and Immuno-Oncology is an open access rapid peer reviewed journal in the field of cancer research. HPV infection is the most commonly diagnosed sexually transmitted disease in the United States (US) and is associated with the development of anal cancer. Anal cancer and its precursor lesions are biologically similar to cervical cancer and caused by persistent HPV infection. A high proportion of anal cancers are associated with HPV types 16 and 18. Each ye... Read More

Self expandable metallic stents (SEMS)

Image ABSTRACT The management of patients presenting with acute large bowel obstructioncaused by left sided colorectal cancer is still debated.Colonic stenting (CS) seems to be a good therapeutical option toemergency surgery: it is able to convert an urgent situation in anelective one. Lately conflicting results were published about thistechnique used as bridge to surgery in comparison with the emergencysurgery in terms of oncologic safety and recurrence rate.Actually self expandable metallic stents (SEMS) are not “allowed”to treat potentially curable patients. Data reported... Read More

Triple negative breast cancer (TNBC)

Image ABSTRACT Triple negative breast cancer (TNBC), a type of breast cancer, is still incurable and 4T1 tumor is an equal experimental model of TNBC which is highly metastatic and invasive. In the present study, we assessed the prophylactic cancer vaccine effects on survival and metastasis in 4T1 tumor bearing mice. Female BALB/c mice were divided in three groups and subcutaneously (s.c) injected with PBS incomplete Freund’s adjuvant (IFA) and a mix of the homogenized 4T1 cancer cells emulsified with IFA, respectively. Also, in the third group, the last immunization was contained... Read More

Arsenic Poisoning from Repeated Exposure to Burning Herbal Products

Image Journal of Clinical Toxicology is an open access peer reviewed journal which publishes articles bi-monthly. Journal provides rapid peer review process. Recently journal has published its 2nd bi-monthly issue of its 10th volume with 5 regular articles and an editorial note.   In its 2nd issue of 10th volume Journal of Clinical Toxicology has published a case-report regarding Arsenic Poisoning from Repeated Exposure to Burning Herbal Products Arsenic poisoning from repeated exposure to burning herbal products containing real... Read More

COVID-19 effect on supply of drugs and vaccines all over the world

Image Vaccines and Immunization When a Vaccine is injected into the body is called as Vaccination. The reaction of the body after administration of vaccine is Immunization. The vaccine stimulates the immune system, recognizes the diseases, protects the body from infection and prevents the spread of diseases to others. Actually, the Vaccination and Immunization meanings are not same but they are often used interchangeably. Human Vaccines-Infectious and Non Infectious Human vaccines are used for infectious diseases in order to increase the immunization rate in host organism and helps in preventing ... Read More

Convulsion After Poisoning of a herbicide containing Pyrazolate

Image Journal of Clinical Toxicology is an open access peer reviewed journal which publishes articles bi-monthly. Journal provides rapid peer review process. Recently journal has published its 2nd bi-monthly issue of its 10th volume with 5 regular articles and an editorial note.   In its 2nd issue of 10th volume Journal of Clinical Toxicology has published a case-report regarding Convulsion After Poisoning of a herbicide containing Pyrazolate and Propyrisulfuron. The cae is well reported by the author Yu Mimura, Michitaka Funaya... Read More

Kidney disease

Image Kidney disease Kidney disease is a complex health problem, often coinciding with cardiovascular pathology (e.g. hypertension) and metabolic disturbances (e.g. obesity and diabetes). It is also a disturbingly fast growing global public health problem, e.g. chronic kidney disease affects an estimated ~9-16% of the population. Besides the public health issues this results in a large economic burden as kidney diseases contributes disproportionally to about a quarter of total health care costs. Experimental and clinical data solidly support the view that... Read More

Mast Cells

Image Mast Cells Mast cells or “Mastzellen” were first described by Paul Ehrlich in his 1878 thesis. The metachromatic cells were shown to be concentrated around blood vessels, nerves, and glandular ducts as well as inflammatory and neoplastic foci. The cells originate from hematopoietic stem cells in the bone marrow. Because of their importance in allergen/IgE-mediated allergic reactions, most of the studies on mast cells have traditionally focused on their role in allergy. However, the last fifteen years have witnessed the changing tide and this field has ... Read More

Stress Immunity

Image Stress Immunity While changes in the environment are perceived as a stress on the body, over time, the body adapts to the changing environment and adjusts accordingly. Stress can be largely divided into two categories; physicochemical stress and psychological stress. Physicochemical stress comprises environmental factors in the form of food/nutrition, noise, pollution, metabolic disorder, infection, and inflammation. Stress also exerts a great influence on the functions of our immune system: if the immune system is somehow compromised and cannot properly cope with... Read More

Psychiatric research | Clinical Research & Ethics

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Extrapulmonary

Image Extrapulmonary If a tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). Symptoms may include chest pain and a prolonged cough producing sputum. About 25% of people may not have any symptoms (i.e. they remain "asymptomatic"). Occasionally, people may cough up blood in small amounts, and in very rare cases, the in... Read More

Abortion and Ethics: Legal Provisions

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Abortion and Ethics : Issue & Analysis

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Clonioc stenting in the management of acute left-sided malignant colonic obstruction is oncologically safe?

Image ABSTRACT The management of patients presenting with acute large bowel obstructioncaused by left sided colorectal cancer is still debated.Colonic stenting (CS) seems to be a good therapeutical option toemergency surgery: it is able to convert an urgent situation in anelective one. Lately conflicting results were published about thistechnique used as bridge to surgery in comparison with the emergencysurgery in terms of oncologic safety and recurrence rate.Actually self expandable metallic stents (SEMS) are not “allowed”to treat potentially curable patients. Data reported... Read More

Pseudochylothorax: An underdiagnosed entity Prophylactic Autologous Cancer

Image ABSTRACT Triple negative breast cancer (TNBC), a type of breast cancer, is still incurable and 4T1 tumor is an equal experimental model of TNBC which is highly metastatic and invasive. In the present study, we assessed the prophylactic cancer vaccine effects on survival and metastasis in 4T1 tumor bearing mice. Female BALB/c mice were divided in three groups and subcutaneously (s.c) injected with PBS incomplete Freund’s adjuvant (IFA) and a mix of the homogenized 4T1 cancer cells emulsified with IFA, respectively. Also, in the third group, the last immunization was contained... Read More

Ant colony optimization Self-organization and Intelligence

Image The group behavior of social creatures has always been a source of inspiration for computer scientists. Collaborative nature of group members exhibits an intelligent behavior which usually, cannot be obtained by any single individual of the group. This intelligent behavior commonly, known as swarm intelligence is implemented by computer scientists in the form of computational algorithms. Ant colony optimization (ACO), particle swarm optimization (PSO), artific... Read More

Innovative Approaches in Dermatology during Covid-19 infection

Image Dermatology is the branch of medicine deals with the skin, nails, hair and its diseases. It concerns the study, research and diagnosis of normal skin and disorders of the skin An expert in the field of dermatology is a dermatologist. A dermatologist may be involved in medical or surgical treatments. Dermatologists also manage the cosmetic disorders of the skin, including hair loss, scars, and the skin changes associated with aging. Skin cancer and also malignancy of epithe... Read More

Nutritional Eye Washing Solution (NEWS)

Image The age-related macular degeneration (AMD) caused vision loss for millions of patient worldly. Lutein and Zeaxanthin can reduce the blue light and ultraviolet damage to the retina and decrease rate of AMD. However, lutein is difficult to be dissolved in water, the lutein as a dietary supplement through mouth may be only very small amount that can reach the eyes. This is a try to use two herbs and four vitamins put in a concentrated nutritional eye washing solution, and use two drops of that concentrated eye washing solution mixed in every one milliliter of saline, and put in an eye cup to w... Read More

Transcatheter Intervention for Late Complications after Aortic Coarctation Surgical Repair

Image Aortic coarctation (CoA) is not uncommon congenital cardiac disease. Surgical repair of native CoA is nowadays a common and safe procedure at early childhood. However, late complications, including re-CoA and aneurysm formation, are not uncommon. The incidence of these complications is dependent on the type of the initial operation. Both transcatheter and surgical repair play important roles in the treatment of late surgical complications. This article will review the incidence of late complications after CoA repair and will discuss the transcatheter treatment options for such complications... Read More

herpes Simplex Virus

Image Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of new viruses that produce viral infections in the majority of humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are common and contagious. They can be spread when an infected person begins shedding the virus. About 67% of the world population under the age of 50 has HSV-1. In the United States, about 47.8% and 11.9% are believed to have HSV-1 and... Read More

Gynaecology : an approach

Image Gynaecology or gynecology (see spelling differences) is the medical practice dealing with the health of the female reproductive system (vagina, uterus, and ovaries). Outside medicine, the term means "the science of women". Its counterpart is andrology, which deals with medical issues specific to the male reproductive system. Almost all modern gynaecologists are also obstetricians (see obstetrics and gynaecology). In many areas, the specialities of gynaecology and obstetrics overlap. In some countries, women must first see a general practitioner (GP; also known as a famil... Read More

Affect of Inflammatory Arthritis on All Age People

Image As ailment, provocative joint inflammation influences individuals everything being equal. It can cause a critical effect on an individual's joints, and furthermore improves the probability of other incessant illnesses. It has higher reason mortality than HIV/AIDS, asthma, and melanoma, yet it was not perceived as a constant illness in Nova Scotia. Joint inflammation can cause agony, solidness and growing around your joints. It is genuinely normal in more established populaces yet joint inflammation influences individuals in all age gatherings, including just about 300,000 kids... Read More

Pathology and Nephropathy Podocyte

Image Pathology and Nephropathy Podocyte Due to its rapidly increasing prevalence, chronic kidney disease (CKD) has become a global health problem. The main causes of CKD include age-related renal function decline, hypertension, diabetes, obesity as well as primary renal disorders. It has been well established that podocytes, the highly differentiated glomerular cells are critical determinants of outcome for all glomerular diseases. The limited ability of mature podocytes to self-renewal is a major cause of progressive kidney diseases, regardless of their diverse origin... Read More

Specific Causes of Back Pain

Image Back pain. It's the #1 reason for incapacity around the world, so chances are you've most likely experienced it. In case you're fortunate, it left following a couple of days. In case you're not all that fortunate, in the same way as other of the 6 million Canadians living with joint pain, it's a consistent partner that seriously limits your capacity to carry on with your life. While the particular reasons for back pain are not surely known, in joint inflammation it is frequently connected with degeneration of the intervertebral circles – the joints that s... Read More

Wild Immunology

Image Wild Immunology Recent advances in technology, particularly with respect to computing power and molecular biology techniques, provide unprecedented research opportunities that once would have just been interesting “thought” exercises. The technological advances have begun to remove barriers such as logistical constraints and lack of species-specific reagents. Despite revolutionary new tools, many long-standing gaps in our understanding of the immune system persist. Supposed cures for cancers and infectious diseases are discovered almost daily in mouse ... Read More

Bacterial Exotoxins: how bacteria fight the immune system

Image Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors to m... Read More

Clinical Toxicology and Venoms, Toxins

Image Journal of Clinical Toxicology has released its volume 2 in its 10th volume in this April in the bimonthly issue. This ‘Research Topic’ deals with the various ‘Venoms, Animal and Microbial Toxins’. It is devoted to the toxins/molecules (and derivatives thereof) from marine and non-marine animal venoms, plants/algae, and microbes. The ‘Research Topic’mainly focuses on the structural characteristics, structure-function relationship, and pharmacology of toxins. It also covers the natural or non-natural/synthetic toxic substances of vario... Read More

Vestibular Deficits in Neurometabolic, Neurogenetic, and Neurodegenerative Diseases

Image The main aim of the Journal of Clinical & Experimental Ophthalmology is to publish high quality research works and provide Open Access to the articles using this platform. The Journal offers a rapid and time bound review and publication that freely disseminates research findings related to JCEO. It caters to the requirements of the medical practitioners, researchers, lab professionals, students, academicians, and industry that are involved in Medical and Optical & Surgical studies. No matter how prestigious or popular, it increases the visibility and impact of published work. It inc... Read More

Ocular activity: Latest issues in clinical ophthalmology

Image Journal of Clinical and Experimental Ophthalmology has successfully completed its 10 years of publication history and successfully issued its 2nd bimonthly issue in this year. The study of eye movement is a rich source of information about brain functioning for neurologists and neuroscientists. The eye movements provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurometabolic and neurogenetic diseases provide insight into their pathophysiology and d... Read More

COVID-19 and Migrants’ Psychosocial Health

Image This Research Topic addresses how resilience and coping strategies are expressed among the most vulnerable communities, and how they are bearing the burden and enduring the most dire consequences of recent crises, not the least the effects of the COVID-19 outbreak. People with migrant backgrounds, refugees, asylum seekers, undocumented migrants, who were already experiencing multifaceted repressions and discrimination, now find themselves in an even more vulnerable situation ranging from immediate socio-economic challenges to barriers of receiving adequate treatment and care. Psychological ... Read More

Adancements and Innovations in Automation and Swarm Intelligence

Image Artificial Intelligence Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of ... Read More

Advances in Immunology & Vaccine Technology

Image A vaccine is an inactivated form of bacteria or virus that is injected into the body to simulate an actual infection. Because the injected microorganisms are 'dead,' they don't cause a person to become sick. Instead, vaccines stimulate an immune response by the body that will fight off that type of illness. It covers infectious disease targets and non-infectious ... Read More

Osteoarthritis and its overview

Image Degenerative joint sickness, which is also implied as osteoarthritis (OA), is a commonplace "mileage" ailment that happens when the tendon that fills in as a cushion in the joints separate. This condition can impact any joint yet is commonly typical in knees, hands, hips, and spine. Osteoarthritis is the most widely recognized type of joint pain, influencing a huge number of individuals around the world. It happens when the defensive ligament that pads the parts of the bargains wears out after some time. Despite the fact that osteoarthritis can... Read More

Degenerative Joint Disease story

Image Degenerative joint illness, which is additionally alluded to as osteoarthritis (OA), is a typical "mileage" malady that happens when the ligament that fills in as a pad in the joints break down. This condition can influence any joint yet is generally normal in knees, hands, hips, and spine. Over half of grown-ups beyond 65 years old are influenced by degenerative joint illness. This condition is related with torment, loss of capacity, and decreased continuance, at last prompting weight gain and related confusions. The basic reason for this condition is commonly intermina... Read More

Cardio-toxicity: Clinical Toxicology

Image Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors to m... Read More

Ecotoxicology and Cytotoxicity of Nanomaterials

Image The turn of the century has seen an explosion in the development of new nanotechnological methods and materials which is leading to an ever-increasing number of commonly used products containing nanomaterials (NMs). According to a recent search (March, 2019) on the Nanodatabase (http://nanodb.dk/), the number of products containing nanomaterials is currently 3036. Engineered nanomaterials, due to their unique physicochemical properties, can be successfully applied in a wide range of contexts such as energy, chemical engineering, electronics, biomedicine, agriculture, food and cosmetics. The... Read More

Behold the Eye in Parkinson's Disease & Alzheimer’s Disease

Image There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop vision problems. This neurological and ophthalmological disorder creates a pressing need for developing therapy to treat vision impairment in AD/PD. On the other hand, pathophysiological changes in the retina may reflect what might happen in the same diseases in the brain. Thus retinal studies may allow us to develop quantifiable measures for the... Read More

Vision in Cephalopods

Image Vision is one of the most important senses we have. Vision care encompasses a number of medical, scientific, and social issues. Journal of Clinical & Experimental Ophthalmology is an important discussion and knowledge dissemination podium for the researchers, students and medical practitioners. This Ophthalmology journal focuses on different aspects of eye surgery such as post lasik conditions and care, surgically induced astigmatism, cataract surgery, corneal transplant success rate, paecilomyces infection, clear corneal incision, post-operative corneal melt, malyugin ri... Read More

Immune System and Health

Image Immune System and Health The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens a... Read More

Immune and HIV

Image Immune and HIV The vision of the Sustainable Development Goals (SDG) is to achieve a better and more sustainable future for all. In the past years, although in the absence of cure or vaccines, the treatment of HIV infection with combination Antiretroviral Therapy (cART) has been pretty successful. Despite this, long term HIV infection is associated with an enhanced and accentuated onset of non-AIDS-related pathologies. For different and not completely defined reasons, long-term treated HIV-infected individuals suffer from some age-related maladies due to chronic i... Read More

J Carcinog Mutagen: Call for Papers

Image Carcinogenesis and Mutagenesis is a friend audited clinical diary in disease science. This Scientific Journal centers around the acknowledgment of cell reactions to DNA harm, apoptosis (cell passing), and inactivation of tumor silencer qualities and examination of the cancer-causing process by hereditary and epigenetic changes in qualities for the investigation of malignancy inception and movement. This journal incorporates all the ongoing issues identified with change and carcinogenesis under its degree. This incorporates understanding general disease cell structure, identificati... Read More

Impact of Metabolic Syndrome Diagnosis and Its Treatment on Survival of Colorectal Cancer Patients

Image Abstract Background. Epidemiologic findings on the effect of metabolic syndrome (MetS) and its treatment on colorectal cancer (CRC) survival have been inconsistent and have not been previously studied in an Arab population such as the Omani population. Patients and Methods. Data from the hospital records of 301 CRC patients treated in Sultan Qaboos University (SQUH), Oman, from 2006 to 2014 were analyzed retrospectively to determine the effects of MetS and its treatment on CRC survival. Overall survival (OS) by MetS status and by medicatio... Read More

Increasing Incidence of Colorectal Cancer in Young Adults

Image Background:  For a long time, phenomenon of defective immune-surveillance in cancer patients from pathological standpoint was not elucidated. I have reported 1985 that lowering seral cyclic AMP is biochemical reason of defective immunesurveillance from adoptive lymphocyte immunotherapy experiment among cancer patients. Recently, Honjo Tasku et al., reported why T cell don’t attack cancer c... Read More

Spatial Partners in Vision: Clinical and Experimental Ophthalmology

Image Journal of Clinical and Experimental Ophthalmology considers articles on clinical ophthalmology related issues such as ophthalmia neonatorum, pterygium histology, aphakic glaucoma, acute zonal occult outer retinopathy (AZOOR), hypertrophic pachymeningitis, phacomorphic glaucoma, pseudoexfoliation syndrome, binasal hemianopsia, bitemporal heteronymous hemianopsia, cycloplegic refraction, cycloplegic drugs, macular edema optical coherence tomography (OCT), juxta fovea retinal telangiectasis, central serous retinopathy treatment, involutional ectropion, impaired depth perception, lacrimal fist... Read More

Microbial Toxins and Venoms, Clinical Toxicology

Image The Journal of Clinical Toxicology (JCT) is Scholarly Open Access journal that deals with the study of xenobiotics and alsostudy toxic effects of agents (drugs) whose purpose is to ameliorate or prevent a disease. The journal addresses both scientific research and clinical advances in clinical toxicology. This free clinical journal provides an open access platform for researcher’s work in clinical toxicology in hospitals, academia, government or industrial sectors. This Scientific journal includes a wide range of fields in its discipline to create a platform for the authors ... Read More

Delayed Recovery from Anesthesia Following Suboccipital Craniotomy: A Case Report and Literature Review

Image   Delayed Recovery from Anesthesia Following Suboccipital Craniotomy: A Case Report and Literature Review Delayed awakening from anesthesia is defined as failure to regain consciousness within 20-30 min Dіer a surgical procedure. Нe most common causes of delayed awakening are benign and mostly related to residual anesthetic eوٴects However,... Read More

Bacteriology & Parasitology is the salient division of Microbiology

Image Bacteriology is the regular part of Microbiology, which centers around fundamental microbiology, have pathogen communications, natural chemistry, sub-atomic science and systems, environment and the study of disease transmission of microscopic organisms. Parasitology is a nearest relative of Medical Microbiology that envelops the parasite world running from protozoans to helminthes. The Journal of Bacteriology and Parasitology is authority diary, which is known for its condition... Read More

Inverse Knapp Procedure for Bilateral Hypoplastic Inferior Rectus Muscles

Image The case of a 39-year-old woman with vertical strabismus with no concordance between intraoperative findings and the preoperative magnetic resonance imaging (MRI) has been presented here. Orbital MRI revealed apparent agenesis of the inferior rectus muscles. After undergoing surgery a satisfactory postoperative result with reduction of lateral incomitance has been observed. A 39-year-old woman presented with incomitant right eye hypertropia (RHT), with bilateral limitation of infraduction and over-depression on adduction of the left eye. Orbital MRI revealed apparent agenesis of t... Read More

Induced Abortion Cannot Become a Human Right

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Phase I Clinical Trial with a Novel Altered Peptide Ligand Derived from Human Heat-Shock Protein 60 for Treatment of Rheumatoid Arthritis: Safety, Pharmacokinetics and Preliminary Therapeutic Effects (jctr)

Image CIGB 814 is an Altered Peptide Ligand (APL) from a CD4+ T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. This clinical trial was conducted to assess safety and pharmacokinetics (PK) of CIGB-814 in patients with RA. 20 patients with moderated active RA were included in an open label trial. Sequential dose-escalation of 1, 2.5 and 5 mg of CIGB-814 was studied. Consecutive groups of six, five and nine patients receive... Read More

Advance Robotics and Health and Safety at Work

Image Artificial Intelligence Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of increasing smart software and systems. In the real life, the knowledge has... Read More

Pulmonary

Image Pulmonary If a tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). Symptoms may include chest pain and a prolonged cough producing sputum. About 25% of people may not have any symptoms (i.e. they remain "asymptomatic"). Occasionally, people may cough up blood in small amounts, and in very rare cases, the infecti... Read More

Epidemiology

Image Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in defined populations. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical res... Read More

Antiretrovirals: HIV and AIDS Drugs

Image HIV medications can help lower your viral load, fight infections, and improve your quality of life. They can lower your chances of transmitting HIV, but if you take them incorrectly, you can still give HIV to others. They're not a cure for HIV. The goals for these medicines are to: Control the growth of the virus Improve how well your immune sy... Read More

AGING

Image Aging Aging represents a paradox of immunodeficiency and inflammation (inflamm-aging) and autoimmunity. Over the lifespan there are changes in the architecture and functioning of the immune system often termed “Immunosenescence”. Recently, there have been major developments in understanding the cellular and molecular bases, and genetic and epigenetic changes, in innate and the adaptive immune system during aging. Limited longitudinal studies have begun to reveal biomarkers of immune aging, which are recognized as an “immune risk profile... Read More

Neurological Disorders

Image Neurological Disorders Tauopathies are characterized by the aberrant modification, splicing, and aggregation of the microtubule-associated protein Tau into filamentous inclusions in neurons and glia. Tau pathology is present across a wide spectrum of neurodegenerative diseases including Alzheimer's disease, fronto-temporal dementias, Pick's disease, progressive supranuclear palsy, chronic traumatic encephalopathy, Huntington's and Parkinson's diseases, among others. Given the combined prevalence of these diseases and the importance of Tau pathology... Read More

Diagnosing and treating eye disorders by Novel Nanotechnology

Image Journal of Clinical & Experimental Ophthalmology (JCEO) brings articles in all areas related to ophthalmology, neuro-ophthalmology, ocular oncology, clinical ophthalmology, experimental ophthalmology, pediatric ophthalmology, eye diseases, ophthalmic imaging, ophthalmscopy, glaucoma, vision research, cataract, cornea and corneal diseases, ocular microbiology, ophthalmic research .As a member of Publisher International Linking Association, PILA, Longdom Publishing SL’s JCEO follows the Creative Commons Attribution License and Scholars Open Access publishing policies.Journal of Clin... Read More

Molecular Mechanism of the Toxicity

Image Journal of Clinical Toxicology - Open Access using online manuscript submission, review and tracking systems of OMICS Group for quality and quick review processing.OMICS Group is using Online Review and Editorial Tracking Systems for quality review process. Editorial Tracking System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publicati... Read More

Intravenous general anesthetics

Image Intravenous general anesthetics Intravenously-delivered general anesthetics are typically small and highly lipophilic molecules. These characteristics facilitate their rapid preferential distribution into the brain and spinal cord, which are both highly vascularized and lipophilic. It is here where the actions of these drugs lead to general anesthesia induction. Elimination Following distribution into the central nervous system (CNS), the anesthetic drug then diffuses out of the CNS into the muscles and viscera, followed by adi... Read More

Modelling Risk and Decisions Analysis

Image Modelling Risk and Decisions Analysis Risks and their management are an integral part of decision making in the 21st century. A decision framework should allow groups of stakeholders to evaluate multiple-objective decisions and analyze trade-offs of various alternatives/scenarios/decision to be considered. However, formulating these alternatives, objectives, and trade-offs involves working with both facts (the uncertain state of the “world” one models) and values (what one deems important). Ideally, the facts and the values should be kept separate even... Read More

Pathology of asthma

Image Pathology of asthma Asthma is a serious health and socioeconomic issue all over the world, affecting more than 300 million individuals. The disease is considered as an inflammatory disease in the airway, leading to airway hyperresponsiveness, obstruction, mucus hyper-production and airway wall remodeling. The presence of airway inflammation in asthmatic patients has been found in the nineteenth century. As the information in patients with asthma increase, paradigm change in immunology and molecular biology have resulted in an extensive evaluation of inflammatory c... Read More

Clinical Toxicology offers rapid peer review process for authors

Image Journal of Clinical Toxicology - Open Access using online manuscript submission, review and tracking systems of OMICS Group for quality and quick review processing.OMICS Group is using Online Review and Editorial Tracking Systems for quality review process. Editorial Tracking System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publicati... Read More

Clinical Toxicology: Drug toxicity and toxins

Image The journal of Clinical Toxicology (JCT) is a broad-based journal founded on two key tenets: To publish the most exciting researches with respect to the subjects of Clinical Toxicology: Secondly, to provide a rapid turn-around time possible for reviewing and publishing and to disseminate the articles freely for research, teaching and reference purposes. It is basically aimed at the Clinical Practitioners, medical/ health practitioners, students, professionals and researchers and professional bodies and institutions. Living organisms, particularly human are exposed to chemical subs... Read More

Public health

Image Public health Public health has been defined as "the science and art of preventing disease”, prolonging life and improving quality of life through organized efforts and informed choices of society, organizations, public and private, communities and individuals".Analyzing the determinants of health of a population and the threats it faces is the basis for public health.The public can be as small as a handful of people or ... Read More

Ophthalmology: Ocular research

Image Journal of Clinical & Experimental Ophthalmology (JCEO) brings articles in all areas related to ophthalmology, neuro-ophthalmology, ocular oncology, clinical ophthalmology, experimental ophthalmology, pediatric ophthalmology, eye diseases, ophthalmic imaging, ophthalmscopy, glaucoma, vision research, cataract, cornea and corneal diseases, ocular microbiology, ophthalmic research. The main aim of the Journal of Clinical & Experimental Ophthalmology is to publish high quality research works and provide Open Access to the articles using this platform. The Journal offers a rap... Read More

Revolutionizing Undergraduate Immunology Education

Image Revolutionizing Undergraduate Immunology Education Immunology has its developmental roots in understanding protection of the host from pathogens, leading to the development of vaccines and subsequently identification of soluble and cellular components of the immune system. Thus, immunology education has historically been tightly linked to infectious disease. Decades of research have demonstrated that the complexity and intricacies of the immune system are far greater than perhaps was once imagined. As a system that interfaces with all other organ systems in the bo... Read More

VISION: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Image Vision is one of the most important senses we have. Vision care encompasses a number of medical, scientific, and social issues. Journal of Clinical & Experimental Ophthalmology is an important discussion and knowledge dissemination podium for the researchers, students and medical practitioners. The eye is the only place in the body where both neurons and blood vessels can be directly visualized. These attributes have led to the common clinical practice for vascular diseases such as diabetes and hypertension, to have ocular assessment as a routine component of their management.... Read More

Spatiotemporal variability Studies- Applications of Remote Sensing

Image The study mapped and analyzed spatiotemporal variability of quarry sites in Mpape District, Bwari Area Council of Abuja. The study used high-resolution IKONOS satellite image, ASTERDEM and Hi-Target Differential GNSS receivers. The result showed that nine quarry sites exist in Mpape with three abandoned and six are active while three are located in the center of Mpape with one active and two abandoned. The depth analysis revealed that the deepest site is 25 m at Julius Berger quarry site and the lowest depth was 6 m at Dantata quarry site. The study also reveals that the rocky surfaces has ... Read More

Revolutionizing Cancer Research

Image Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread.Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements.While these symptoms may indicate cancer, they can also have other causes.Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol... Read More

Experimental Cardiology

Image On behalf of the Journal of Clinical & Experimental Cardiology, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been ten long years we have started the Journal, now we are celebrating the 10th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Clinical & Experimental Cardiology. ... Read More

Remote sensing applications in detecting oil spills to preserve the marine life

Image An Oil spill is due to contamination of seawater due to an oil pour. It can happen due to an accident or due to oil release. Being the most important energy sources in the world, Oil is transported through ships across the oceans to different countries. IT is also transported through pipelines via land. This transport which provides numerous benefits to the mankind has also resulted in several accidents in the past while transferring the oil to vessels and due to breakage of pipelines. These spills contaminate the coasts and estuaries and can cause serious health problems ... Read More

Corona Virus : A novel Pandemic

Image Coronaviruses are a group of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can be mild, such as some cases of the common cold (among other possible causes, predominantly rhinoviruses), and others that can be lethal, such as SARS, MERS, and COVID-19. Symptoms in other species vary: in chickens, they cause an upper respiratory tract disease, while in cows and pigs they cause diarrhea. There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections. Coronaviruses constitute the subfami... Read More

Clinical & Experimental Cardiology: Submissions Open

Image Journal of Clinical & Experimental Cardiology (Volume 10, Issue 11) with ISSN : 2155-9880 and the Journal impact factor of 1.79, is an Open Access Journal which is substantially functioning and publishing excellent quality research and eagerly anticipating in framing up an eminent, outstanding upcoming issue with best quality research articles for Open Access readers. This Journal accepts submissions from all th... Read More

A Rare Case of Submandibular Gland Metastasis as the First Sign of Adenocarcinoma of the Lung

Image Introduction Lung carcinomas are aggressive malignancies, characterized by early metastatic spread and poor prognosis at the time of presentation. Metastasis of non-small cell lung carcinoma to submandibular gland is rare. The diagnosis of a metastatic lesion is challenging, both to the clinician and to the pathologist. This case is a rare condition, in our knowledge it is the fourth of the literature. We present a 57-year-old male patient with lung adenocarcinoma reveleated by a tumefaction of the submandibular gland.   Case Prese... Read More

Biochemical Meaning of Defective Immune: Surveillance in Cancer Patients

Image Background:  For a long time, phenomenon of defective immune-surveillance in cancer patients from pathological standpoint was not elucidated. I have reported 1985 that lowering seral cyclic AMP is biochemical reason of defective immunesurveillance from adoptive lymphocyte immunotherapy experiment among cancer patients. Recently, Honjo Tasku et al., reported why T cell don’t attack cancer c... Read More

Innovations in Automation and Artificial Intelligence Automation, Robotics and Vision Engineering

Image Artificial Intelligence Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of increasing smart software and systems. In the real ... Read More

Vaccines Paradigms: Global Approaches in Viral Infection & Immune Response

Image Vaccines and Immunization When a Vaccine is injected into the body is called as Vaccination. The reaction of the body after administration of vaccine is Immunization. The vaccine stimulates the immune system, recognizes the diseases, protects the body from infection and prevents the spread of diseases to others. Actually, the Vaccination and Im... Read More

A Homemade Herbal Beer Containing 15 Eye-Beneficial Herbs Designed for Glaucoma Patients and People with Bad Eye Circulations (JEDD)

Image The blood supply of eyeball is mainly depending on a very thin central retinal artery and circulates back to the small vein, both of them are located in the center of the ocular nerve cord at the back of the eyeball, which is rather similar to a cherry fruit attached to a tiny stalk. It is an unreasonable design for our eye nutritional supply. The very thin central retinal ... Read More

Efficacy of Early Adalimumab or Immunomodulator on Postoperative Remission Maintenance in Patients with Crohn's Disease (JCTR)

Image This study aim was to clarify the efficacy of early adalimumab (ADA) and azathioprine (AZA) in Postoperative recurrence of Crohn’s disease (CD). In a 78-week single-center prospective study, patients with bowel resection were randomly assigned to ADA 160-80-40 mg subcutaneously (SC) or AZA 0.5-1.5 mg/kg/day. The primary endpoint was endoscopic remission at 18 months (Rutgeerts i0, i1 and Simple endoscopic score for CD (SES-CD) ≤ 4). ... Read More

Abortion and Ectogenesis: Bioethics

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Clinical Trials on Drugs

Image Clinical trials  are experiments or observations done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy... Read More

Pupil (jedd)

Image Pupil Definition   The pupil is the opening in the center of the iris (the structure that gives our eyes their color). The function of the pupil is to allow light to enter the eye so it can be focused on the retina to begin the process of sight. Pupil Function Together, the iris and pupil control how much light enters the eye. Using the analogy of a camera, the pupil is the aperture of the eye and the iris is the diaphragm that controls the size of the aperture. The size of the pupil is contro... Read More

The Horns of Dilemma: Life or Sovereignty?

Image Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide... Read More

Perioperative Risk Factors and Predictive Model Proposal of Ultra-Fast-Track Failure and Prolonged Hospital Length of Stay in a Preliminary Protocol of Enhanced Recovery after Off-Pump Coronary Artery Bypass Grafting by Left Anterolateral Thoracotomy Approach (ERAS)

Image   Journal of Perioperative Medicine is a peer-reviewed open access scientific journal. The journal is dedicated to the global advancement of surgical research, education and clinical practice. Journal of Perioperative Medicine aims to promote continued developments in surgery through the sharing of knowledge, innovated ideas across all surgical specialties. ... Read More

Advancements and Innovations in Automation and Swarm Intelligence

Image Artificial Intelligence Artificial Intelligence is a region of software engineering that emphasises the production of intelligent machines that work and respond like people. Artificial intelligence is expert in studying how human brain thinks, learn, decide, and work while trying to solve a problem, and then using the products of this study as a source of increasing ... Read More