Identification of genes defining the immune defects may identify new target genes for therapeutic approaches
Identification of genes defining the immune defects may identify new target genes for therapeutic approaches
Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which result from defects in the immune system. Identification of genes defining the immune defects may identify new target genes for therapeutic approaches. Alternatively, genetic variations can also help to define the immunological pathway leading to disease.
Yes, a healthy diet and good nutritional status is essential for a fully functioning immune system, but that is not ... Read More
Most of the Digestive Autoimmune Diseases
How T cells are involved and it’s role for vaccine development for corona virus
Immunogenetics: Open Access is the Journal that discuss about the branch of medical genetics that explores the relationship between the immune system and genetics. Here we are explaining about a study suggest role of autoimmunity in Parkinson's disease.
A standard 
Nutrition could help your immune system fight off the coronavirus
The coronavirus presents many uncertainties, and none of us can completely eliminate our risk of getting COVID-19. But one thing we can do is eat as healthily as possible. Research shows improving nutrition helps support optimal immune function. Micronutrients essential to fight infection include vitamins A, B, C, D, and E, and the minerals iron, selenium, and zinc.
Here’s what we know about how these nutrients support our immune system and the foods we can eat to get them.
... 
One way in which cancer cells flourish is by concealing themselves against cytotoxic immune cells.
Putting a type of immune cells in natural killer cells
Natural killer (NK) cells are lymphocytes in the same family as T and B cells, and are part of the innate immune system. They circulate throughout the body and are among the first to respond to the presence of foreign cells or invaders, most notably viruses and early signs of cancer.
First, they created NK cells from IPSCs, which are derived from skin or blood cells that have been reprogrammed back to an embryonic-like pluripotent state and then directed to become NK cells. This strategy produces a s... 
The ability to use of DNA binding domains (DBDs) able to interact with a specific DNA target in order to develop synthetic proteins capable of modifying gene expression or the functioning of DNA recombination machinery, such as those involving endonucleases, integrases or transposases (Tpase), constitutes a major challenge in the post genomic era. From this perspective, a DBD added to an enzymatic system has to combine several qualities, including i) being bound to a DNA target large enough to ensure specific and high-affinity recognition, ii) having a controllable ability to assemble (or n... 
5-carboxylcytosine (5caC) is an important derivative of cytosine modification in DNA demethylation pathway. However, the accurate quantification of 5caC is a challenge, especially in mammalian tissue. This plight probably results from the trace amount of 5caC in mammalian and the inadequate sensitivity of the existing technologies. Herein, we report a novel LC-MS/MS method to precisely quantify 5caC in mammalian cells. The 5caC standard reagent was synthesized, and the genomic DNA was hydrolyzed with formic acid and the target compound 5caC was detected by HILIC LC-MS/MS. The results showed... 
A Note on Immune Response to Environmental Exposure and Immunoregulation Properties
Two different immune system which work together
The immune system protects your child's body from outside invaders. These include germs (such as bacteria, viruses, and fungi) and toxins (chemicals made by microbes). The immune system is made up of different organs, cells, and proteins that work together.
The innate immune system
This is your child's rapid response system. It is the first to respond when it finds an invader. It is made up of the skin, the eye's cornea, and the mucous membrane that lines the resp... 
MicroRNAs in Microglia
The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and pathological conditions. MicroRNAs (miRNAs) are short, non-coding epigenetic regulators that repress target gene expression mostly via binding to 3′-untranslated region (3′-UTR) of mRNA in a Dicer-dependent manner. Dysregulation of certain miRNAs can contribute to micr... 
A Study finds that Bat 'super immunity' may explain how bats carry coronaviruses
Immunogenetics: Open Access is the Journal that discuss about the branch of medical genetics that explores the relationship between the immune system and genetics. Here we are explaining about a study suggest role of autoimmunity in Parkinson's disease.
A standard 
Human trial of COVID-19 vaccine
Immunogenetics is the branch of medical genetics that explores the relationship between the immune system and genetics. Here we are explaining about a study suggest role of autoimmunity in Parkinson's disease.
The combination delayed tumor progression in multiple mouse models of colorectal cancer; in some mice
They're small spiny mammals that look like anteaters with scales.
Genetic research into the new coronavirus has suggested that it originated in bats, found its way into pangolins sold at Chinese "wet markets," and then migrated into humans.
So why doesn't the virus sicken and kill pangolins?
In a new study, researchers at the Medical University of Vienna in Austria analyzed the genomic blueprint of pangolins and compared it to other mammals... 
Abnormal CFTR protein
The Scientists, Professors, Research scholars, Doctors can publish their high quality papers for worldwide viability on our online platform. This Genetics journal is using Editorial Tracking System for online manuscript submission. Manuscript can be submitted through online portal system 
Inherited Blood Anemia- decreases red blood cells
Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood ... 
Alcoholic Liver Disease
Alcohol consumption is an important social, economic, and health problem. Heavy alcohol consumption results in a wide range of multi-organ pathology, including alcoholic liver disease (ALD) which is a major cause of alcohol-related morbidity and mortality in the United States and Worldwide. The clinical spectrum of ALD ranges from fatty liver to alcoholic hepatitis, fibrosis and cirrhosis, which may progress even further to hepatocellular carcinoma. ALD has limited prevention and therapeutic options. Therefore, understanding the molecular ... 
Mechanotransduction plays a major role in Immune response
The most cited article in Immunogenetics: Open Access is “MHC Genotyping from Rhesus Macaque Exome Sequences”
Clopidogrel is an antiplatelet drug used to minimize the risk of heart failure and stroke in people at high risk. It is also used in heart attacks and after the insertion of a coronary artery stent (dual antiplatelet therapy) along with aspirin. It's mouth-taking. Effects start about two hours and last for five days
Medical use
Clopidogrel is used to avoid heart attack and stroke in people at high risk for these conditions, including those with a history of myocardial infarction and other types of acute coronary syndrome, stroke, and... 
Molecular diagnostics: Molecular diagnostics is a set of techniques used to examine biological markers in the genome and proteome by applying molecular biology to medical testing-the genetic code of the organism and how their cells express their genes as proteins
Achondroplasia is a form of short limb dwarfism that has captured man's imagination since ancient times. It is the most common skeletal dysplasia in humans which caused by defect in cartilage-derived bone. The prevalence is estimated to be 1 in 12,000, and it is usually recognized at birth
M... 
Inherited Blood Anemia
Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels ca... 
Genetic Disorder: Gene therapy technique
The Scientists, Professors, Research scholars, Doctors can publish their high quality papers for worldwide viability on our online platform. This Genetics journal is using Editorial Tracking System for online manuscript submission. Manuscript can be submitted through online portal system 
T Cells in Immunity
T follicular helper cells (Tfh) are professional B cell helper cells in germinal centers (GCs), lymphoid structures where B cell maturation into high affinity plasma cells and memory B cells takes place. Upon antigen encounter, a fraction of T cells upregulates chemokine receptor CXCR5 that allows their locali-zation inside the B cell follicles where together with dendritic cells and B cells initiate the GC response. These CXCR5-expressing T cells upregulate Bcl-6, acquire the full differentiation program of the Tfh cell lineage, and help B cel... 
The measurement of antibodies specific to COVID-19
Skin Cancer
Understanding the microenvironment within skin cancers is key for the development of new preventative and therapeutic treatment options. Research advances in skin cancers such as melanoma have revolutionized immunotherapeutic treatment options, for example through the provision of checkpoint inhibitor trials that have benefitted not just melanoma patients, but also patients with a wide array of other cancers, including less readily accessible cancer types. However, checkpoint inhibitor success is limited in melanoma and unlikely to become the mainstay ... 
Skin Functions
The search for further knowledge on skin functions and mechanisms is at the core of many biomedical and biopharmaceutical research programs today. The extension and complexity of the skin justifies its multiple roles, affecting all physiological processes, far beyond its “barrier” characteristics. More research on skin physiology is needed to better understand various disease mechanisms, and these need not be confined to the skin itself. Skin is also a target for new molecules, supplements, materials and even instruments, with the potent... 
Sickle cell anemia
Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and orga... 
Cystic fibrosis
The Scientists, Professors, Research scholars, Doctors can publish their high quality papers for worldwide viability on our online platform. This Genetics journal is using Editorial Tracking System for online manuscript submission. Manuscript can be submitted through online portal system 
A biomarker in medicine is a observable measure of the extent or occurrence of a state of illness. More broadly, a biomarker is something that can be used as an indication of a specific disorder of an organism, or any other physiological state.
A biomarker can be a material introduced into an organism as a way of testing organ function or other health aspects. Rubidium chloride, for example, is used in isotopic labelling to test heart muscle perfusion. It can also be a substance whose identification indicates a medical disease, e.g. the presence of an antibody may... 
Phenotype (from Greek phenotype, meaning 'showing' and form, meaning 'type') is the word used in genetics for an organism's composite measurable features or traits. The term includes the morphology or physical shape and structure of the organism, its mechanisms of growth, its biochemical and physiological properties, its behavior and the behavioral products. The phenotype of an organism results from two fundamental factors: the form, or genotype, of the genetic code of an organism and the effect of environmental factors
Phenotypic variation: Ph... 
Chromosomal polymorphism is a disorder of genetics where one population includes members of different counts or shapes of the chromosome. Polymorphism is a general phenomenon in biology where a population includes more than one variant of a trait. In certain instances, with different counts, the variation in chromosome numbers is the product of a single chromosome being split into two smaller chromosomes, or two being fused, where two chromosomes join together to form one.
Implications for speciation: All types of chromosome polymorphism can be seen as a step in t... 
Role of Autoimmunity in Parkinson’s Disease
Azurin is a thin, periplasmic, blue copper protein found in the bacteria Pseudomonas, Bordetella, or Alcaligenes. Azurin enhances single-electron transmission between cytochrome-associated enzymes by oxidation-reduction between Cu(I) and Cu(II), azurine tetramer's monomer has a molecular weight of about 14kDa, contains a single copper atom, is intensively blue and has a fluorescent emission band centered at 308 nm
Azurin is a protein of the tetrameric type. Each monomer weighs around 14kDa and consists of 128 amino acids which form eight beta-strands arranged in a beta-barrel ... 
What is the immune system exactly, and how does it help repel intruders
Immune systems will need to adapt unaided to COVID-19. The immune system is the body’s multi-level defence network against potentially harmful bacteria, viruses and other organisms.
The corona virus pandemic has turned the world’s attention to the immune system, the body’s defence force against disease-causing bacteria, viruses and other organisms that we touch, ingest and inhale every day.
Think of it as the body’s personal army working from the cel... 
Ribonucleic acid (RNA) is a polymeric molecule responsible for the coding, decoding, control and expression of genes in various biological roles. RNA and DNA are nucleic acids, and along with lipids, proteins, and carbohydrates, they are the four main macromolecules central to all known life forms. As with DNA, RNA is assembled as a nucleotide chain
Several RNA molecules play an active role within cells by catalyzing biological reactions, regulating the expression of genes, or detecting and transmitting cellular signal responses. One such active process is protein synthesis, a uni... 
The essential oil is a concentrated hydrophobic liquid containing plant chemical compounds which are volatile (easily evaporated at normal temperatures). Essential oils are also referred to as volatile oils, ethereal oils, aetherolea, or simply as the plant oil from which they were extracted, such as clove oil. An essential oil is "necessary" in the sense that it contains the "essence" of the fragrance of the plant-the characteristic fragrance of the plant from which it derives. The word "important" used here does not indicate that the human body is indispensab... 
Genetically modified foods (GM foods), often referred to as genetically engineered foods (GE foods), or bioengineered foods are foods developed from species that have made modifications to their DNA using genetic engineering methods. Genetic engineering techniques allow new traits to be added as well as greater control of traits compared to previous methods, such as selective breeding and mutation breeding.
The Flavr Savr tomato was the first genetically modified food approved for release in 1994. Developed by Calgene, it was designed to have a longer shelf life by adding an antis... 
Animal Diseases
The Belt and Road Initiative (BRI) is a global development strategy adopted by the Chinese government in 2013. This investment and infrastructure development strategy drives the world's economic development. However, this initiative has resulted in an increase in transnational spread of animal diseases, which caused a significant economic loss to the global animal industry. For example, in 2013, Peste des petits ruminant virus entered China; in 2015, a Senecavirus A outbreak occurred in China; in 2018-19, African swine fever virus swept into ea... 
Gene Expression of COVID-19
Special issue
COVID-19 Genomic RNA
The Scientists, Professors, Research scholars, Doctors can publish their high quality papers for worldwide viability on our online platform. This Genetics journal is using Editorial Tracking System for online manuscript submission. Manuscript can be submitted through online portal system 
Boost up Immune System to fight off Covid-19
TranscriptLongdom Publishing is a total set of transcripts in a given organism and referred to as an expression profiling that examines the expression level of mRNAs in a given cell population. TranscriptLongdom Publishing includes high-throughput techniques based on 
The 
Covid-19: Immunity can help us to fight the Pandemic
Male Genital Tract Immunology
The male reproductive tract is the primary site for the maintenance of male reproduction and hormone secretion, as well as the entry point of sexually transmitted pathogens. On the one hand, the immune regulation of the male genital tract maintains normal spermatogenesis while on the other hand, the local microenvironment of the immune system plays a key role in preventing the invasion by pathogenic microorganisms.
Infection and inflammation of the male genital tract are thought to be the primary etiological factors of ... 
Genetic Map of COVID-19
The Scientists, Professors, Research scholars, Doctors can publish their high quality papers for worldwide viability on our online platform. This Genetics journal is using Editorial Tracking System for online manuscript submission. Manuscript can be submitted through online portal system 
Healthy Diet and Good Nutritional Status is Essential for Immune System
We are from the Journal 
Contiguous Gene Syndrome (CGS)
contiguous gene syndrome (CGS)
A 
DNA – RNA ; Gene Expression
Identification of Co-inhibitory Receptors PD-1 and TIM-3 on T Cells from Gastric Cancer Patients
A short note about the most common side effects of immunotherapy
Cementoblasts
The research areas related to Odontology are divided as types of steroids such as Oral Steroids etc. 
Gene Syndrome & Gene therapy- Open Access[volume 11]
DNA - RNA- Transcription
What is Autoimmune disease and most types of Autoimmune diseases
Immunogenetics: Open access journal focuses on the genetic research areas of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, Crohn’s disease, diabetes mellitus type 1, systemic lupus erythematous, etc. Articles on genetics of cell interaction with immune system, immune response to transplantation, immune based therapies for treatment of cancers, antigenic phylogeny of alleles, alloantigens are also welcome.
An autoimmune disease is a disease that changes the way... 
Fish | Shellfish Pathology
The study of fish and shellfish diseases requires a wide knowledge, not only of the potential pathogens, but also of the environmental constraints and specialist adaptations, which govern the ectothermic, aqueous, existence of teleosts. The inflammatory and immune responses are greatly modified by the nature of their environment. These in turn influence the epizootiology and the clinical characteristics of the various conditions and the methods by which they can be controlled. Fish and shellfish pathology is clearly a multidisciplinary f... 
A brief explanation about Immunogenetics
Immunogenetics is the study of the mechanisms of autoimmune diseases, tolerance inorgan transplantation, and immunity to infectious diseases-with a special emphasis on the role of the genetic make-up of an organism in these processes. The immune system evolved essentially to protect vertebrates from a myriad species of potentially harmful infectious agents such as bacteria, virus, fungi and various eukaryotic parasites. However, the growing understanding of the immune system has influ... 
RNA to protein- Translation
Gene Syndrome & Gene therapy- Open Access
A major international study of the genetics of breast cancer
Immunogenetics: Open access journal focuses on the genetic research areas of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, Crohn’s disease, diabetes mellitus type 1, systemic lupus erythematous, etc.
Immunogenetics is the branch of medical genetics that explores the relationship between the immune system and genetics.
The majority of the DNA is identical between individuals, but there are some differences, known as genetic variants, and these changes can... 
Improved Peptide-MHC Class II Interaction Prediction Through Integration of Eluted Ligand and Peptide Affinity Data
Author Name: Keith Howell
Category: Genetics and molecular Biology
The 
On behalf of the Journal of Cell Signaling , as 
Germline Cells
Genetic Syndromes & Gene Therapy
Journal of 
Importance of Mechanotransduction in Immune Responses
The current major focus of immunology is how our immune systems are regulated. In particular, how different receptors at the surface of immune cells respond to the presence of either antigen or pathogen, and how these responses are regulated at a subcellular level. But we should keep in mind that biophysical cues generated by physiological events, either normal or abnormal, also influence our immune system. The development of new technologies and interdisciplinary approaches has allowed us to investigate physic... 
Antarctic Fish IgT, a Weird Option of Immunoglobulin Genes
Antarctic fish, most of which belonging to the Perciform Suborder Notothenioidei, have acquired, during their evolution, specific features that allow them to thrive, at present, at cold and stable temperature (-1.86°C). Нe morphological evolution and diversification of Antarctic Notothenioid teleosts into over 120 species is one of the best examples of adaptive radiation in the marine environment. New ecological chances, for instance the extinction of antagonists, the colonization of vacant niches, or... 
Non-Germline Cells
Hereditary Material
Journal of 
The field of Cancer Epidemiology is a dynamic and constantly evolving area of research and clinical application. A key focus of Cancer Epidemiology is to quantify the incidence and prevalence of the disease and to measure outcomes such as morbidity and mortality. Typically, the goal is to identify putative risk factors by comparing exposed with unexposed populations and using epidemiologic techniques including causal inference and survival analysis to assess cancer risk. Etiologic factors may be environmental in nature (e.g., pesticides, electromagnetic fields, UV radiation, groundwater con... 
The 
Cell signaling is a process through which living cells interact with the cellular environment and neighbouring cells. Cells contain Glycoproteins or Glycolipids as receptors on their plasma membrane which detects the signals. When a complementary ligand (signaling molecule) comes and binds to the receptor, it initiates a chain of reactions within the cell, ultimately leading to a response.
The 
SYNTHETIC BIOLOGY - THE "CONSTRUCTION" OF LIFE
Current Synthetic and System Biology initially treated (micro)organisms such as bacteria as if they were small computers with exchangeable parts. Genes were seen analogous to electronic components. The plan was to systematically construct organisms or their genomes from such components. Some concepts looked promising, ie to be able to produce a substance against malaria, genes from a plant were transferred to yeast fungi. Ultima... 
The auditory perception of sounds (environmental, speech or music) is one of the 5 principal senses consciously monitored by our brains, and is hugely important for all human endeavors and one’s quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators.
The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, mo... 
Immunogenetics: OpenAccess has announced offer on its membership
It gives us great pleasure to announce the call for paper on the occasion of 04th Anniversary of the Journal .The Journal of 
Author Name: Keith Howell
Category Name: Genetics and molecular Biology
Description: CRISPR gene cuts may offer new way to chart human genome.
On behalf of the 
Genesity
NLM ID: 101574143
Index Copernicus Value 2016: 84.15
The Journal of 
Chromosome
Journal of 
AIM and Scope of Immunogenetics: Open Access
The main aim of the 
Biological system
Current Synthetic and Systems Biology is an academic journal that provides an opportunity to researchers and scientist to explore the advanced and latest research developments in the f... 
Expression of a Gene
On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy.
The Journal of 
Evolutionary Trends in Gene Therapy
The Journal of 
Are KIR-HLA Polymorphisms Relevant for the Outcome of Chronic Infected Hepatitis C Virus Patients?
HCV is a major public health problem worldwide with an estimated population of 71 million people suffering from chronic hepatitis C infection. Approximately 3,99,000 people die each year from hepatitis C, mostly from complications like cirrhosis and hepatocellular carcinoma (HCC). HCV prevalence varies around the world. Regarding HCV genotypes in Europe, the most common subtype is 1b whilst in America the most frequent subtype is 1a. In the Middle East, North and Cen... 
A Short Review of Immunochemistry
Immunochemistry (IC) provides the basis of molecular mechanisms associated with immune system functions as it relates to the nature of antibodies, antigens and their interactions. Нe various methods in immunochemistry have been developed and refined and been used in scientific study, from virology to molecular evolution. Нe application of the methods of physical chemistry to the study of the theory of toxins and antitoxins has been published by Svante Arrhenius in 1907 which described immunochemistry.
Immunochemistry h... 
More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV). Persistently infected individuals can develop chronic liver disease, cirrhosis and hepatocellular carcinoma. HBV and HCV share numerous pathogenic mechanisms and strategies of immune escape. Cytotoxic, helper, and regulatory T cells, dendritic cells (DCs), natural killer (NK), iNKT, and B cells play important roles in HBV and HCV clearance.
T cell responses are crucial to prevent and control viral infection; however, virus-specific T cell activities may... 
The Research Topic is designed to feature the latest innovative and leading-edge research, reviews and opinions on the study of complex and dynamic processes related to the mammalian immune system and cancer. All papers will be meticulously selected to present our readers the multidisciplinary approach to tackle the existing challenges faced in these important fields.
From high throughput experimental methodologies to computational and theoretical approaches, the articles are intended to introduce physicists, chemists, computer scientists, biologists and immunologists the idea of ... 
Gene Expression - Translation
Genes encode proteins and proteins dictate cell function. Therefore, the thousands of genes expressed in a particular cell determine what that cell can do?. Moreover, each step in the flow of information from DNA to RNA to protein provides the cell with a potential control point for self-regulating its functions by adjusting the amount and type of proteins it manufactures. At any given time, the amount of a particular protein in a cell reflects the balance between that protein's synthetic and degradative biochemical pathways. On t... 
Contiguous gene syndrome
Cancer is one of the most vicious disease which is devastating many lives psychologically, physically and in an unhealthy manner. The treatment of cancerous diseases is becoming a major challenge for the scientists and researchers working on chemotherapeutic agents.
Traditional pillars of cancer treatment – Surgery, Radiation, and Chemotherapy are moving to two new efficacious approaches: Cancer genomics and immunotherapy.
Cancer genomics is the study of the totality of DNA sequence and gene expression differences between tumour cells and norm... 
HLA Allele Distribution in Romanian People: Clinical Significance and Utility Related to Population Genetic Background
He HLA complex is defined by the genes of the Major Histocompatibility Complex (MHC). Нese loci play a key role in the immune system response and are among the most polymorphic in humans, comprising more than 20 genes, Here loci have been studied extensively for at least four reasons: (i) for donor-recipient matching in organ and stem cell transplantation success, (ii) due to associations between polymorphisms and response to infectious diseases ... 
MHC Genotyping from Rhesus Macaque Exome Sequences
Diagnostic Biomarkers
Diagnostic biomarkers are used to confirm that a patient has a particular health disorder. For example, the presence of mutations in the CFTR gene indicate that a newborn has cystic fibrosis. It is “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.”
An biomarker has certain characteristics that make it useful for checking on one’s health or disease conditions. An ideal marker should be:... 
Author Name: Keith Howell
Category: Genetics and molecular Biology
Duchenne type muscular dystrophy (DMD) is the most common hereditary muscular disease among children, leaving them wheelchair-bound before the age of twelve and reducing life expectancy. Researchers at Technical University of Munich (TUM), Ludwig Maximilian University of Munich (LMU) and the German Research Center for Environmental Health (Helmholtz Zentrum München) have developed a gene therapy that may provide permanent relief for those suffering from DMD.
... 
It gives us great pleasure to announce the call for paper on the occasion of 05th Anniversary of the Journal .The Journal of 
Extracellular vesicles (EVs) including exosomes, microvesicles, and apoptotic bodies are membrane-bound vesicles which are secreted by almost all cell types to the cellular microenvironments and circulation. EVs contain bioactive cargoes such as antigens, cytokines, chemokines, membrane proteins, lipids, microRNAs, and long non-coding RNAs that have the ability to elicit cellular responses. EVs can be released by and also be targeted toward immune cells and act as key mediators of cellular communications. EVs carry specific molecular signatures reflecting the status of parental cells at the... 
The development of technologies to better characterize patient disease states, including methods such as sequencing, microarrays, metabolomics, and proteomics from multiple tissues, has produced datasets with potential utility in discovering new targets and identification of patients who might benefit from a given therapy. However, establishing a context for the high dimension content of omics datasets is necessary in order to maximize their predictive potential for the impact of single or combination therapies. Progress towards frameworks for omics data interpretation has arguably been une... 
Genetic disorders
Journal of 
WFS patients
The 
A 
NEW ISSUE RELEASE ON GENETICS
Gene- Encoding proteins
Over the past decade, novel forms of cancer therapies, collectively referred to as cancer immunotherapies, have emerged and yielded spectacular results in unfortunately still a minority of cancer patients. Immunotherapies mobilize the immune system to promote or restore effective anti-tumor immune responses. Pioneer approaches targeting the CTLA-4/B7 and PD1/PDL1 immune checkpoint axes have now reached broad clinical applications. Such treatments often yield sustained benefits, but strong responses are observed in only a minority of treated patients, whereas resistance to immune checkpoint ... 
Dendritic cells (DCs) play a critical role in orchestrating antitumor immune responses due to their capability of regulating innate and adaptive immunity. DCs can elicit tumor specific cytotoxic immunity through both the induction of antigen-specific CD4+ and CD8+ T lymphocytes and the stimulation of killing activity of innate immune cells, such as NK cells and NKT cells. Although a compelling body of preclinical studies strongly supports the potential application of DCs in the treatment of solid and hematologic tumors, DC-based immunotherapy remains rarely used in the clinical practice. Mo... 
This “Research Topic” is a call for papers to provide an up-to-date overview of current efforts to understand the immunological mechanisms of neoantigen directed T-cell immunity and the attempts to harvest this source of antigens for cancer immunotherapy. Recently, the work of different groups revealed that neoepitope-specific T cells are crucial for clinical responses mediated by adoptive transfer of autologous TILs or by immune checkpoint inhibitors. Moreover, ongoing clinical trials demonstrated clear evidence for the feasibility of individualized vaccination or adoptive cell... 
Immunotherapy is a modern and extremely promising treatment for non-small cell lung cancer (NSCLC) patients, often providing long-term clinical benefits or even, in some cases, a complete recovery. Although many patients can now benefit from this form of treatment, the major limitations include high variability in response to treatment and difficulties in the proper qualifications for therapy.
Precise predictive factors for immunotherapy have not been determined yet, and this remains subject to further research. Examination of PD-L1 expression on cancer cells and tumor mutati... 
Immunotherapy, which activates the body’s immune system, has drawn great attention in recent years due to its significant effects. It has been more than 100 years since the first immunotherapy report in 1911 by Leonard Noon. In 1954, Frankland reported the first double-blind placebo-controlled randomized trial in immunotherapy. Since then, immunotherapy has been utilised in different diseases, including asthma and reactions to skin allergens.
Harnessing the immune system for therapeutic benefit in cancer has long been an aim of immunologists and oncologists.... 
The feat, reported in the scientific journal Nature Biotechnology, offers gene therapy designers what may be the first viable technique for adjusting the activity levels of their therapeutic genes. The lack of such a basic safety feature has helped limit the development of gene therapy, which otherwise holds promise for addressing genetically based conditions. The scientists' technique appears to solve a major safety issue and may lead to more use of the strategy.
... 
NEW 2020 ISSUE ON GENETICS
Gene Encode proteins
A baseline of healthy ageing
Every person has around 
The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes are turned on or off. It might seem counterintuitive that bits of DNA that randomly move about the genome can provide stability to these folding patterns. Indeed, the discovery contradicts a long-held assumption that the precise order of letters in the DNA sequence always dictates the broader structure of the DNA molecule.
In places where the larger 3D folding of the genome is the same between mice and humans, ... 
Genetic Syndrome and Gene Therapy New Arena
Visakhapatnam, 29-11-2019
The Journal of 
Gene Expression New arena
Visakhapatnam, 29-11-2019
Journal of Genetic Syndromes & Gene Therapy enhancing the academic communication between scholars and seeking professionals to join as an editorial board Member (or) reviewer team.
The Journal of 
miRNAs are a class of endogenous, small, noncoding, ~22 nucleotides single-stranded RNAs that act as posttranscriptional regulators in eukaryotes . They have reported to be located mostly within noncoding regions of genomes, and usually transcribed from RNA polymerase II promoters . The generation of mature miRNA is a complicated enzyme-catalyzed process, from the initial transcript pri-miRNA to the precursor (pre-miRNA) with a characteristic hairpin structure, then a miRNA duplex 
Author Name: Keith Howell
Category Name: Genetics and molecular Biology
Description: Cell Structure of Human cell recently discovered
The structure is a new type of protein complex that the cell uses to attach to its surroundings and proves to play a key part in cell division.The cells in a tissue are surrounded by a net-like structure called the extracellular matrix. To attach itself to the matrix the cells have receptor molecules on their surfaces, which control the assembly of large protein complexes i... 
Immunotherapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies.
In recent years, immunotherapy has become of great interest to researchers, clinicians and pharmaceutical companies, particularly in its promise to treat various forms of cancer.
Immunomodulators: Immunomodulators are the acti... 
Cancer immunotherapy (sometimes called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the disease. It is an application of the fundamental research of cancer immunology and a growing subspeciality of oncology. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules (e.g. carbohydrates). Normal antibodies bind to... 
Over the past two decades, medicine has been moving towards data-driven diagnoses and personalized therapies based on molecular information.1 Oncology is a prime example, with an ever-growing range of precision drugs designed to target specific driver mutations in cancer cells. However, while these drugs have provided some benefits, they have failed to transform survival in most tumor types.
Frustratingly, identification of a particular genetic alteration is not enough to guarantee that a treatment will work. For example, drugs targeting the overactive V600E f... 
Every person distills down to a script of DNA, and researchers are increasingly mining this genetic information to better inform care. Now, scientists have shown how RNA -- an offshoot of DNA -- is coming into its own as doctors sleuth out difficult-to-diagnose illnesses.
In a new study in Nature Medicine, Stephen Montgomery, PhD, a Stanford associate professor of pathology and of genetics, shows why the transcriptome, the collection of RNA molecules in a cell, is a crucial clue to help decipher the source of some rare diseases.
I had a chanc... 
Gene Mutations
Journal of Genetic Syndromes & Gene Therapy
Journal of 
Immunotherapy: Open Access was congratulating its authors of most cited articles. The article entitled “
Cancer immunotherapy is a therapy used to treat cancer patients that involves or uses components of the immune system. Some cancer immunotherapies consist of antibodies that bind to, and inhibit the function of, proteins expressed by cancer cells. Other cancer immunotherapies include vaccines and T cell infusions.
Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone thera... 
Journal of Cancer Research and Immuno-Oncology is one of the most promising and rapidly developing areas of cancer research. The journal focuses on the development of new therapies which improve human body’s immune response against cancer.Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in the area of cancer biology, tumor and stem cell biology, immunology, microenvironment and immunology, molecular and cellular pathobiology, immuno-oncology, prevention and epidemiology, therapeutics and targets.
... 
The 
Genetic syndromes-New 2020 Issue
Journal of 
Gene Mapping
NLM ID: 101574143
Index Copernicus Value 2016: 84.15
The Journal of 
Immunotherapy: Open Access has recently published an article entitled “Multiplex Immunohistochemistry: The Importance of Staining Order WhenProducing a Validated Protocol” in its volume 5 Issue 2 written by Jihad Syed, Jack Ashton, Jesuchristopher Joseph, Gemma N Jones, Christian Slater, Alan Sharpe,Garry Ashton, William Howat, Richard Byers, Helen K Angell from Institute of Cancer Sciences, University of Manchester, Manchester, UK and Translational Medicine, Oncology R&D,&nbs... 
Chimeric antigen receptor T cell (CAR-T) therapy has shownsignificant efficacy in treating patients with refractory B-cellleukemia and lymphoma [1,2]. However, CAR-T therapy hasyielded less favorable results in treating patients with solidtumors such as pancreatic, ovarian or mesothelioma cancers[3-5]. One of the major obstacles in treating solid tumors withCAR-T is the scarcity of antigen that is uniformly expressed intumor cells such as CD19 in B cell hematologic malignancies[6,7]. Therefore, designing a CAR against an antigen that ishighly expressed in cancer cells but either has negligi... 
Journal of Immunotherapy: Open access features rapid publication of articles on immunomodulators, lymphokines, antibodies, cells, and cell products in cancer biology and therapy. Laboratory and preclinical studies, as well as investigative clinical reports, are presented. The journal emphasizes basic mechanisms and methods for the rapid transfer of technology from the laboratory to the clinic. IMT contains full-length articles, review articles, and short communications.
Instructions for authors are as follows:
Manuscrip... 
Gene Expression - RNA to protein
Gene Syndrome
Gene Expression
Visakhapatnam, 29-11-2019
On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy.
The Journal of 
Evolutionary Trends in Gene
Visakhapatnam, 29-11-2019
The Journal of 
On behalf of the 
In recent years, technological advancements in transcriptomics (the process of studying a cell’s complete set of 
Mechanism of Low Endotoxin Recovery Caused by a Solution Containing a Chelating Agent and a Detergent
Mechanism of Low Endotoxin Recovery (LER) was investigated by observing the change in particle sizes and activity of endotoxin in LER solutions containing sodium citrate and polysorbate 20. Interestingly, endotoxin aggregates were not dispersed to be smaller particles under LER conditions according to the decease of the activity. This observation was different from previous predictions of the mechanism. Endotoxin aggregates were observed by Dynamic Light Scatterin... 
The Journal is successfully running in the 4th Volume which covers a wide variety of specialties including 
New Issue Release 2020 -Journal of genetics syndrome and gene therapy[Upcoming Issue]
The 
Genetic syndromes
Journal of 
Who are we?
The “
Current research on Genetic Syndrome and Gene Therapy
The Journal of 
Use of genomics to balance cure and complications
The Journal of 
On behalf of the 
The 
Updated Science on Genetics
NLM ID: 101574143
Index Copernicus Value 2016: 84.15
The Journal of 
Wolfram Syndrome- Rare Genetic Syndrome
Wolfram syndrome
Journal of 
On behalf of the 
Science Advancements in Gene Expression
Visakhapatnam, 29-11-2019
On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy.
The Journal of 
On behalf of the 
Evolutionary Trends in Genetic Syndrome and Gene Therapy
Visakhapatnam, 29-11-2019
The Journal of 
The editorial team of 
Bipolar Disorder: Open Access, is an international scholarly, peer reviewed journal in the field of neuropsychopharmacology, neuropathology, genetics, brain imaging, epidemiology, phenomenology, clinical aspects, and treatments of bipolar disorders. Journal expresses its warm gratitude to especially the Editorial Board, and extending this gratitude to all the Authors, researchers, Editors and Students who have contributed their valuable researches in the form of full article, case reports to this journal.
The Journal mainly focusses to serve its readers. Journal was started in the... 
Spreading knowledge globally, Research on Cell activity
The 
Cell & Developmental Biology journal has attained a unique identity among journals of cell and development. On this eve, we express our sincere gratitude towards editorial board for their endless support, help and service. It also extends a very warm welcome to all the researchers, scientist and scholars to contribute their latest finding as full length article to this Journal.
Mycobacterial Diseases celebrates more than a decade of its existence in the field of clinical publishing and research and extends a very warm welcome to all the authors, researchers, editors and student to contribute their latest research findings as full length articles to this collaborative health journal. The journal is committed to serve its readers authors by adding the state of the art facilities to enhance the author’s scholarly visibility.
Established in the year 2011, Mycobacterial Diseases is one of the most reputed journals of Longdom group, the medical publ... 
The