Liver Transplant
Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. The most common technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic position as the original liver. The surgical procedure is compl... Read More
Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage kidney disease. Kidney transplantation is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation depending on the source of the donor organ.
Living-donor kidney transplants are further characterized as genetically related (living-related) or non-related (living-unrelated) transplants, depending on whether a biological relationship exists between the... 
Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.
Psoriasis is a chronic disease that often comes and goes. The main goal of treatment is to stop the skin cells from growing so quickly.
There is no cure for psoriasis, but you can manage symptoms. Lifestyle measures, such as moisturizing, quitting smoking and managing stress, may help.
Symptoms
Psoriasis s... 
1) Zeposia (ozanimod) Capsules
Company: Bristol-Myers Squibb Company
Date of Approval: March 25, 2020
Treatment for: Multiple Sclerosis
Zeposia (ozanimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS).
2) Isturisa (osilodrostat) Tablets
Company: Novartis Pharmaceuticals Corporation
Date of Approval: March 6, 2020
Treatment for: Cushing's Syndrome
Isturisa (osilodrostat) is a cortisol synthesis inhibitor ind... 
Overview
Infectious diseases are transmitted from person to person by direct or indirect contact. Certain types of viruses, bacteria, parasites, and fungi can all cause infectious disease. Malaria, measles, and respiratory illnesses are examples of infectious diseases.
Simple preventative measures, such as frequent hand washing, can cut down on disease transmission.
Direct contact
Infectious diseases are often spread through direct contact. Types of direct contact include:
1. Per... 
The problem of antibiotic resistance in bacteria has reached the crisis stage. Coincident with ever-increasing rates of resistance to conventional antibiotics is the slowing in development of novel-acting antibiotics by the pharmaceutical industry. The convergence of these trends has led to the relatively common occurrence of multidrug- and extensively drug-resistant bacteria. The World Health Organization recently reported that “a postantibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibi... 
Author Name: Keith Howell
Category Name: Medical science
Description:
Nuclear Factor kappa-light-chain-enhancer of activated B cells or 
Author Name: Keith Howell
Category Name: Medical science
Description:
In highly organized biological systems like multicellular organisms, tight regulation of growth and death is imminent. If cells are no longer required, they commit suicide by activating an intracellular death program. This method of programmed cell death is called 
When a doctor tries to figure out the cause of a disease, they are actually trying to figure out the etiology of the disease. Etiology is the cause of a disease or the science that deals with such causes. The word etiology comes from the Greek etio-, which means 'causation' and -ology, which refers to the scientific study of something.
You might be familiar with similar terms such as biology and geology. These words also refer to the scientific study of something. Biology is the study of life (... 
The heart of IMMULITE 1000 is the proprietary Test Unit, which offers a breakthrough in automated bead washing. The Test Unit, containing an assay-specific coated bead, serves as the reaction vessel for all sample processing. Spinning the Test Unit at high speed efficiently expels fluid into the integral sump chamber. The tube design allows for multiple discrete washes within seconds, ensuring excellent separation of unbound material for highly sensitive assays. IMMULITE 1000's unique wash technique produces extremely low and consistent nonspecific binding, which is critical for assay ... 
To describe a rare case with generalized tetanus to reinforce the relevance of early detection and management. Case report: A 38 year old Pakistani man presented with neck stiffness to the emergency room 12 d after he had trivial nail injury to his foot for which he didn’t need to seek any medical advice. Tetanus was diagnosed based on clinical symptoms and history. The management consist of antibiotics therapy with penicillin-metronidazole, tetanus toxoid and tetanus imm... 
Prostatic adenocarcinoma (PCa) is one of the major contributors to malignancy in men worldwide and second leading cause of cancer death after lung cancer. PCa is an aggressive disease and shows a strong predilection to metastasize into the bones and pelvic lymphatic nodes. In contrast, the metastatic spreads into testicles are rare, accounting up to 4% of all prostate cancer (PCa) cases. Here we present a case from our practice of unilateral testicular metastasis, developed secondary to prostatic carcinoma and diagnosed 6 months after radical prostatectomy. A 69-year-old man presented to ou... 
Author Name: Keith Howell
Category Name: Medical science
Description:
There are more than 100 different autoimmune diseases. But what unites them all is that they arise from an individual's own cells rare and mysterious immune cells that target not external viruses and bacteria but the body's own healthy organs and tissues.
For the first time, Researchers have pinpointed individual cells that cause autoimmune disease from patient samples. They also uncovered how these cells 'go r... 
Author Name: Keith Howell
Category Name: Medical science
Description:
A new USC study suggests that temporarily suppressing the body's immune system during the early stages of 
Invasive Aspergillosis is an opportunistic mycotic infection witha mortality rate of 15-30% depending on when the infection isdiagnosed and type of therapy elected.
While therequirement for a diagnosis of proven invasive pulmonaryaspergillosis remains a lung biopsy for histopathology andculture, these patients are immunocompromised by definitionand such an invasive procedure is often not recommended.
Empiric treatment, likewise, is not ideal because the an... 
We have published several studies related to Invasive Pneumococcal Disease, and effectiveness of Pneumococcal Conjugate Vaccines: 7-valent (PCV7) and 13-valent (PCV13). This is the first Latin American, prospective study looking for Otomastoiditis (OM) in children, and the impact of PCV13 on this disease. Methods: Since October/1st/2005 until September/30th/2017, prospective surveillance to identify all children<16 years old with OM at the Tijuana, Mexico, General Hospital was performed. OM was diagnosed with otoscopy, and tomographic signs of ... 
The function of living organisms is determined by the behavior of chiral compounds and their reactions. Not only the RNA and DNA influence this function, but the enantiomers of amino acids and sugars also have a dominant role. So, it is not surprising that an increasing number of drugs contain single enantiomers, which are often prepared by resolution of racemic compounds obtained due of chemical syntheses. The therapeutically effect of enantiomers can be different, and it is not rare that these effects are opposite.
A tragic reminder of the importance of chirality is thalidomide,... 
High-Performance Thin Layer Chromatography (HPTLC) is a reliable and rapid method useful for the detection of product quality and composition. In recent times, HPTLC instrumentation allows to obtain fingerprints suitable to determine composition and identity of plant raw materials. This study aimed at exploring the results of High-performance Thin Layer Chromatography (HPTLC) analysis as a useful means for the authentication of Allanblackia parviflora kernel and seed oils using the fingerprint approach. Sixteen bulked kernel and seed oil samples from 16 different communities were a... 
With delayed treatment, schistosome and soil transmitted helminth (STH) infections in young children (<5 years)could potentially lead to irreversible lifelong detrimental health effects. This is because these infections are known tocause suboptimal growth and development in this critical phase of life. The present study sought to document theburden of schistosome and STH infections in Taita Taveta County, Kenya, by determining the prevalence andintensity of the infections in children less than 5 years of age. The study al... 
Tree nut allergic individuals are often sensitised towards multiple nuts and seeds. The underlying cause behind a multi-sensitisation for cashew nut, hazelnut, peanut and birch pollen is not always clear. We investigated whether IgE cross-reactivity between cashew nut-, hazelnut- and peanut proteins exists in children that are multi-allergic to these foods using a novel IMMULITE®-based inhibition methodology, and investigated which allergens might be responsible. In addition, we explored if an allergy to birch pollen might play a role in this cosensitisatio... 
Human doping refers to the use of performance-enhancing drugs by the athletes. Human sport doping control analysis is a complex and challenging task for anti-doping laboratories. The field is regulated by the World Anti-Doping Agency (WADA), whose aim is to achieve globally harmonized results and equal treatment for all athletes. The List of Prohibited Substances and Methods is updated annually by WADA and consists of hundreds of chemically and pharmacologically different low and high molecular weight (MW) compounds.
In sports, today the aim is to provide equal opportunities for a... 
Quick, sensitive and specific detection of infectious agents can aid in better treatment of patients and forrecognition of contaminants. Traditional methods suffer from drawbacks of being time consuming and tedious toperform and modern medicine advances call for better detection methods. Strategies employing nanoparticle basedsystems are under investigation to allow for efficient and rapid detection of pathogenic microorganisms.Nanoparticles have been conjugated with nucleic acid probes and antibodies to serve as one step detection system,based on conserved genomic DNA sequences and specifi... 
Reference data for clinical chemistry on reference values of children in Taita Taveta County are fundamental for clinical diagnosis, management and research. In such a study, a target sample population of 120 respondents is usually required. In this study, a total of 577 healthy subjects from Taita Taveta population were employed to generate the normal reference data on eight clinical chemistry markers. The data obtained will provide needed information to medical practitioners with regards to patient management, as well as conducting research studies on disease.... 
Nanoelectromechanical systems (NEMS) are enabling important emerging applications in diverse fields ranging from quantum measurement to biotechnology. In general, the smaller a device, the more susceptible are its physical properties to perturbation by external influences. This enhanced sensitivity of NEMS is opening a variety of unprecedented opportunities for applications such as mass spectrometry, which is now widely used for proteomics. Furthermore, to reliably detect the expression of low-level signals and to understand the fundamental biological processes, it is important to develop t... 
Detailed chemical analysis of water is a prerequisite for assuring the safety of water supplies. Limitations in our ability to identify contaminants in water also limit our ability to assure water quality and to assess environmental impacts. Recent improvements in analytical techniques have expanded the "analytical window," that is, the compound range that is amenable to specific identification. Using these improved tools, much has been learned about the occurrence, fate, and transport of organic chemicals in the environment. The boundaries of the analytical window represent the &... 
Author Name: Keith Howell
Category Name: Medical science
Description:
The findings, from researchers suggest the 
Murine coronavirus, mouse hepatitis virus (MHV), causes various diseases depending on the strain and route of inoculation. Both the JHM and A59 strains, when inoculated intracranially or intranasally, are neurovirulent. Comparison of the highly virulent JHM isolate, JHM.SD, with less virulent JHM isolates and with A59 has been used to determine the mechanisms and genes responsible for high neuropathogenicity of MHV.
The focus of this review is on the contributions of viral spread, replicati... 
Author Name: Keith Howell
Category Name: Medical science
Description:
Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth factors, hormones, neurotransmitters, and extracellular matrix components are some of the many types of chemical 
The mass spectrometry (MS) resources on campus aim to provide researchers with state-of-the-art techniques and equipment to characterize biomolecules including proteins and peptides (proteomics, sugars including glycoproteins (glycemic), metabolites (metabolomics) and lipids (lipidomics). A number of state-of-the-art instruments for the separation of biomolecules and their analysis by mass spectrometry-based approaches are available. In addition to providing analytical services, the mass spectrometry facility on campus provides training to on-campus scientific staff on the use of this techn... 
Author Name: Keith Howell
Category Name: Medical science
Description:
A clear theme that emerges is the enormous complexity that underlies most cellular responses and the vast variety of proteins and interaction/binding motifs used to transduce 
Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.
Psoriasis is a chronic disease that often comes and goes. The main goal of treatment is to stop the skin cells from growing so quickly.
There is no cure for psoriasis, but you can manage symptoms. Lifestyle measures, such as moisturizing, quitting smoking and managing stress, may help.
Symptoms
... 
In recent years, major settling or tilting of buildings and bridges, instability of dams and road embankments have been observed and many attempts have been made in order to mitigate such damages. In this regard, it is necessary to determine the soil improvement alternatives, technically and economically, from the ultimate state design in accordance with geotechnical categories, to stabilize and remediate the existing soft problematic soils prior to the commencement of any construction activities. The aims of improving soils (as foundation and construction materials) are to increase strengt... 
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). It is a major global health problem. It can cause chronic infection and puts people at high risk of death from cirrhosis and liver cancer.
A safe and effective vaccine that offers a 98-100% protection against hepatitis B is available. Preventing hepatitis B infection averts the development of complications including the development of chronic disease and liver cancer.
Transmission
In highly endemic areas, hepatitis B is most commonly spread from... 
Author Name: Keith Howell
Category Name: Medical science
Description:
Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in 
Author Name: Keith Howell
Category Name: Medical science
Description:
The analysis of public genome sequence data from SARS-CoV-2 and related viruses found no evidence that the virus was made in a laboratory or otherwise engineered. By comparing the available genome sequence data for known 
Chloroquine and hydroxychloroquine have drawn more attention—and certainly more presidential support—than any other drug during the global quest to find an effective coronavirus therapy.
Now, days after the FDA gave them an emergency approval to treat COVID-19, European regulators are limiting their COVID-19 use to clinical trials only.
The decision comes as limited data—some of it questionable—rolls in about the drugs and their potential as COVID-19 therapies. A French study that's made headlines continues to draw fire, bu... 
The COVID-19 pandemic and the ensuing societal countermeasures are upending operations in many sectors—and biopharma isn't immune.
The current lockdown is not only hurting clinical trial enrollment but also delaying regulatory timelines for drugs nearing a decision. And with tried-and-true, in-person marketing techniques no longer allowed, new launches may also feel the pain—or hold off altogether.
Consider Bristol Myers Squibb and its big new approval for multiple sclerosis drug Zeposia. It's a long-awaited med, but BMS is postponing the launch under... 
Author Name: Keith Howell
Category Name: Medical science
Description:
The researchers say that pairing 
1) Zeposia (ozanimod) Capsules
Company: Bristol-Myers Squibb Company
Date of Approval: March 25, 2020
Treatment for: Multiple Sclerosis
Zeposia (ozanimod) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS).
2) Isturisa (osilodrostat) Tablets
... 
The problem of antibiotic resistance in bacteria has reached the crisis stage. Coincident with ever-increasing rates of resistance to conventional antibiotics is the slowing in development of novel-acting antibiotics by the pharmaceutical industry. The convergence of these trends has led to the relatively common occurrence of multidrug- and extensively drug-resistant bacteria. The World Health Organization recently reported that “a postantibiotic era—in which common infections and minor injuries can kill—far from being an apocalypt... 
The interaction of the gastrointestinal 
The interest of 
In the last ten years, placenta, fetal membranes (i.e. amnion and chorion), and amniotic fluid have been extensively investigated as a potential non-controversial source of stem cells. They are usually discarded after delivery and are accessible during pregnancy through amniocentesis and chorionic villus sampling. Several populations of cells with multi-lineage differentiation potential and immunemodulatory properties have been isolated from the human placenta and fetal membranes; they have been classified by an international workshop as human amniotic epithelial cells (hAECs) [human amniot... 
As the need and interest for producing renewable biofuels and biochemical has grown, new avenues to improve product yields and productivity have been explored. Specifically, improving the tolerance of host microbes towards stressors, such as heat shock or the presence of harmful solvents, has been an especially important route to improve industrial-scale chemical production. In this review, we discuss recent advances in microbial engineering for renewable chemical production through the introduction and expression of chaperonins, especially the bacterial GroE complex.
The GroE com... 
An ultrasound scan finds its applications in medical and research field . The ultrasound technology uses high-frequency sound waves to create images of the internal organs of the body. The major benefit of ultrasound is it does not utilize or emit any radiation that causes harm to the human body. Thus it is also suitable for use during pregnancy.An ultrasound is recommended for heart, kidneys, bladder, brain (in infants), eyes, liver, ovaries, pancreas, spleen, thyroid and other body organs.
Another important application of ultrasound is found under water where ... 
Metabolism is chemical reactions occurring in organisms. Without enzymes metabolism wouldn’t be fast enough to support life. Metabolism refers to all the chemical reactions occurring in organisms.
Chemical composition:
Enzymes are made of protein.
Protein consists of one or more polypeptide chain.
These are made of long chains of amino acids connected by peptide bonds.
Structure of Enzymes:
In enzymes, the polypeptide chain is folded into a 3D shape.
A par... 
The original idea of using enzyme as detergents was described in 1913 by Dr Otto Rohm, who patented the use of crude pancreatic extracts in laundry pre-soak compositions to improve the removal of biological stains. In the same year, the first enzymatic detergent named Burnus was launched, but was not popular because of its own limitations. Subsequently, Bio- 40 - a detergent containing a bacterial protease was produced in Switzerland and launched in the market in1959 and it gradually became popular. In the period from 1965 to 1970, use and sale of detergent enzymes grew very fast.
... 
The past year has seen a wider application of knowledge originating over the last decade rather than startling new developments. For brevity, only serum enzymes will be considered and the points at which progress is being made are indicated by the sectional headings which follow.
ENZYME METHODOLOGY:
Considerable change is taking place in established enzyme methods and new forms of methodology are being developed. Colorimetric kinetic assays Together with the familiar ultraviolet (UY) kinetic assays, newer kinetic assays utilising wavelengths in the visi... 
Here are some examples of enzyme biotechnology you might use every day in your own home. In many cases, the commercial processes first exploited naturally occurring enzymes. However, this does not mean the enzyme(s) being used were as efficient as they could be.With time, research, and improved protein engineering methods, many enzymes have been genetically modified. These modifications allow them to be more effective at the desired temperatures, pH, or other manufacturing conditions typically unsuitable for enzyme activity (e.g. harsh chemicals). They are also more applicable and efficient... 
The 
Journal of Developing Drugs is an open access publishing that aims to focus on the Drugs, and also related to Chemistry and Pharmacy. Journal of Developing Drugs deals with chemical compounds found in Drugs that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design.
Articles such as original research papers, review articles, short communications, case reports and commentaries are welcome. Articles related to Drug Metabolism, Drug Designing, Clinical Trails, Drug Discovery, Biopharmceutics, Pharmacokinetics and Pharmacodynamic... 
Enzymes are known to catalyze more than 5,000 biochemical reaction types.Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Enzymes are sensitive to external conditions and therefore have unstable characteristics. High temperature, strong acid, alkali and some heavy metal ions will lead enzyme to lose activity and useless. Enzymes are generally difficult to preserve, which brings great difficulties to a wide range of applications.
According to the function of the enzyme, enzymes are usual... 
Enzyme is a kind of catalytic protein produced in the body, functioning as a catalyst. The catalyst can accelerate the chemical reaction without the change of amount and chemistry after the chemical reaction. All enzymes are macromolecules made up of many amino acids with a molecular weight between 10,000 and 1,000,000. Natural enzyme molecules include simple enzymes and binding enzymes. The former molecular composition contains only protein, the latter contains non-protein components, as well as protein composition.
Some also contain metal ions. Non-protein components in enzymes ... 
Biomedical Research: Grab and bag huge citations with BMR
Protein engineering is a powerful tool in synthetic biology that can create proteins with tremendous potential for therapeutic and industrial use. The field has recently taken giant leaps forward from its origins, and some of its pioneers predict that the next five to ten years hold exponentially more promise. Early protein engineering was what David Baker, Ph.D., director of the Institute for Protein Design at the University of Washington, called “Neanderthal protein design.” “You’d look around in nature for something where you could make a couple of amino acid subs... 
Engineered proteins can be used to optimize desired traits in plants; even though recent advances have resulted in new application areas, certain methodological challenges remain. Protein engineering and directed evolution are powerful technologies for probing protein sequence-function relationships. These methods have been used to engineer both plant-derived proteins and exogenous proteins heterologously expressed in plants.
In this review, we aim to further increase the interdisciplinary crossover between the disciplines of protein engineering and plant biology by first introduc... 
Researchers demonstrate that resveratrol, the ingredient which is found in red wine, prevents the growth of breast cancer cells by stopping the growth effects of estrogen.
These study results suggest that resveratrol is capable of counteracting the malignant progression as it suppresses the spreading of hormone resistant breast cancer cells. The discovery has significant implications for treating breast cancer in women whose tumors at some point develop a resistance to hormonal therapy.
The researchers made use of a number of breast cancer cell lines that express the est... 
According to a study, 2 drugs made use of for treating type 2 diabetes may be associated with a significantly higher risk of the development of pancreatic cancer and pancreatitis, and 1 of the drugs may be associated with an increased thyroid cancer risk. Researchers analyzed the FDA’s database for adverse events reported by individuals making use of the type 2 diabetes drugs exenatide and sitagliptin. A 6 times the increase in the odds ratio for reported pancreatitis cases with these drugs was found, in comparison to 4 other diabetes control therapies. It was also found that individu... 
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Antitumor Antibiotics
Antitumor antibiotics are chemo treatments made of natural merchandise made by species of the soil plant life actinomycete. These medication act throughout multiple phases of the cell cycle and are thought of cell-cycle specific. There are many forms of growth antibiotics:
Anthracyclines: antibiotic, Daunorubicin, Epirubicin, Mitoxantrone, and Idarubicin.
Chromomycins: Dactinomycin and Plicamycin.
Alkylating Agents
Alkylating agents are most active wit... 
[ISSN: 2167-7700 | Index Copernicus Value: 62.73]
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A vast body of research, collected over decades, has confirmed that 
Enzymes are known to catalyse more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction rate by lowering its activation energy. Some enzymes can make their conversion of substrate to product occur many millions of times faster. An extreme example is orotidine 5'-phosphate decarboxylase, which allows a reaction that would otherwise take millions of ... 
Enzymes are both proteins and biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyse individual steps. The study of enzymes is called enzymology&nbs... 
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RESEARCH & REVIEWS: JOURNAL OF MEDICAL AND HEALTH SCIENCES
Prioritizing Medical and Health Sciences Journal to Get the Most out Publishing Industry/Publishing Journey
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Endocrinology & Metabolic Syndrome Accomplished 8 Years Milestone in Research Publication Journey
The journal welcomes write-ups for possible publication in the form of original research articles, review articles, and clinical studies from all the relevant subject categories.
On the grand occasion of 10th anniversary, 