The T-Cell Predominance: Angioimmunoblastic T-Cell Lymphoma

Image The T-Cell Predominance: Angioimmunoblastic T-Cell Lymphoma Journal of Cancer Research and Immuno-Oncology is an open access peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc A lymph node based T-cell lymphoma which originates from a T follicular helper cell phenotype may cogitate the angio-immunoblastic T cell lymphoma (AITL) or... Read More

Delayed Immune-Related Erythrodermia in a Squamous NSCLC Patient Treated with Nivoluma

Image Delayed Immune-Related Erythrodermia in a Squamous NSCLC Patient Treated with Nivoluma Journal of Cancer Research and Immuno-Oncology is an open access peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy et Immunotherapy has been changing the scenario of the treatment of non-small cell lung cancer (NSCLC) and is leading to a dramatic i... Read More

Malaria Drug Helps Virus Patients Improve, in Small Study

Image A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed. The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week. Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more... Read More

EXPERTS DISCUSS COVID-19 AND WAYS TO PREVENT SPREAD OF DISEASE

Image Experts from Johns Hopkins University met today for a webcast discussion of the latest developments in the ongoing coronavirus outbreak, including efforts to study the virus and methods of reducing the spread of illness. The conversation was moderated by Joshua Sharfstein, vice dean of public health practice and community engagement for the Bloomberg School of Public Health. Virologist Andy Pekosz, an expert in microbiology and immunology, provided an update on the status of two vaccine trials, the first of which began this week in Washington state and the second of whic... Read More

Journal of Cancer Research and Immuno-Oncology

Image Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It is a peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc This Journal provides a unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on any array of latest canc... Read More

Co-expression of PD-L1 Antibodies Enhances the Anti-Tumor Efficacy of Chimeric Antigen Receptor T Cells

Image Co-expression of PD-L1 Antibodies Enhances the Anti-Tumor Efficacy of Chimeric Antigen Receptor T Cells Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc This Journal prov... Read More

How to boost immune response to vaccines in older people

Image SUMMARY: Identifying interventions that improve vaccine efficacy in older persons is vital to deliver healthy aging for an aging population. Immunologists have identified a route for counteracting the age-related loss of two key immune cell types by using genital wart cream to boost immune response to vaccination in aged mice. After this validation in mice, the findings offer an attractive intervention to tailor the make-up of vaccines for older people. Research just published by the Linterman lab shows that the immune system of older mice can be given a helping h... Read More

Antibody Therapeutics in Oncology

Image Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It is a Peer Reviewed Open Access Journal supported by universally prominent Editorial Board members.. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc. This Journal provides a unique forum dedicated to scientists to express their research articles, review articles, case reports and short c... Read More

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

Image Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Intestinal mononuclear phagocytes (MNPs) have a crucial role in maintaining epithelial barrier integrity while controlling pathogen invasion by activating an appropriate immune response. However, in genetically predisposed individuals, uncontrolled immune activation to intestinal flora is thought to underlie the chronic mucosal inflammation that can ultimately result ... Read More

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

Image Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia first emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other provinces and other countries. Angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV and has been suggested to be also the receptor for 2019-nCoV. Paradoxically, ACE2 expression in the lung protects mice from SARS-CoV spike protein induced lung injury by attenuating the renin-angiotensin system. In the intestine, ACE2 also suppresses intestinal inflammation by maintaining amino acid homeostasis, antimicrobial... Read More

Isolevuglandins promote autoimmunity and hypertension in systemic lupus erythematosus

Image Hypertension, vascular inflammation and renal inflammation are characteristic of systemic lupus erythematosus (SLE), a multisystem autoimmune disease that is complex and poorly understood. Oxidation products of arachidonic and other fatty acids, termed isolevuglandins (isoLG) lead to formation of post-translational protein modifications that are immunogenic. We demonstrate isoLG enrichment in dendritic cells (DCs), B cells, and plasma cells from juvenile female B6.SLE123 mice. In adult B6.SLE123 and NZBWF1 mice, isoLG adducts are enriched in plasma cells and splenic DCs compared to C57Bl/6 ... Read More

Association Study of PTPN22 (rs2476601) and PADI4 (rs2240340) Polymorphisms with Rheumatoid Arthritis in Algerian Population

Image An association between protein tyrosine phosphatase 22 (PTPN22) and Peptidylarginine deiminase 4 (PADI4) genes with rheumatoid arthritis (RA) has been demonstrated in several populations. The present study investigated whether PTPN22 and PADI4 genes polymorphisms were involved in the genetic predisposition to RA in the Algerian patients. Materials and methods: The PADI4_94 (rs2240340) and the PTPN22 (rs2476601) Single Nucleotide Polymorphisms (SNPs) were genotyped in 300 RA patients and 306 healthy controls by real time polymerase chain reaction method (TaqMan Assa... Read More

Type I and II Interferon are Associated with High Expression of the Hippo Pathway Family Member's

Image The Hippo pathway plays a regulatory role on inflammation and cell death and proliferation. Here we described a relationship between Hippo pathway components and inflammation in healthy subjects. The plasma levels of cytokines and chemokines were used to define their inflammatory profile and classify them as normal, high and low producers of cytokines. Leukocytes from healthy subjects with inflammatory profile expressed the highest levels of MSTS1/MST2, SAV1, LATS1/LATS2, MOB1A/MOB1B and YAP genes. The group that overexpressed Hippo pathway-related genes secreted more IFN-ϒ and IFN-&a... Read More

Type I and II Interferon are Associated with High Expression of the Hippo Pathway Family Members

Image The Hippo pathway plays a regulatory role on inflammation and cell death and proliferation. Here we described a relationship between Hippo pathway components and inflammation in healthy subjects. The plasma levels of cytokines and chemokines were used to define their inflammatory profile and classify them as normal, high and low producers of cytokines. Leukocytes from healthy subjects with inflammatory profile expressed the highest levels of MSTS1/MST2, SAV1, LATS1/LATS2, MOB1A/MOB1B and YAP genes. The group that overexpressed Hippo pathway-related genes secreted more IFN-ϒ and IFN-&a... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinoma

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells a... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas : J Clin Cell Immunol

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known. Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using whole sections. Measured tumor-infiltrating plasma cells a... Read More

A Case Series of Rheumatic Immune-Related Adverse Events in Patients with Immune Check Point Inhibition

Image Background: Immune check point inhibitors (ICIs) have a potent anti-tumour effect and up to 43% of people receiving therapy will develop rheumatic adverse effects (RirAEs). People with pre-existing autoimmune disease (AID) were excluded from clinical trials. Aim: To define the characteristics of rheumatic symptoms in people on ICIs for malignancy and subsequent prescribed immunosuppression to manage adverse events. Methods: A case series formed from a retrospective audit of the Northern Territory Top End Health Service e... Read More

Increased Plasma Cells and Decreased B-cells in Tumor Infiltrating Lymphocytes are Associated with Worse Survival in Lung Adenocarcinomas

Image Introduction: Clinical significance of tumor-infiltrating plasma cells and B-cells in lung adenocarcinoma is not well known.  Methods: CD3, CD20 and MUM1 immunostains were performed on representative tumor blocks selected from 120 consecutive lung adenocarcinoma cases treated by surgical resection at Mayo Clinic Rochester. CD3+ T-cells, CD20+ B-cells, and MUM1+ plasma cells were enumerated separately in the intraepithelial (IE) compartment and the stroma (ST) by digital image analyses using w... Read More

On the Ambiguity of Firsts

Image The author, Stanley Shostak, on his article “On the Ambiguity of Firsts: Symbiogeny and Evolutionary Creativity”, states that he want to take issue with static concepts of origins. Predecessors of what exists at present are not necessarily what came first. The abstract of the article says: It isn’t as i... Read More

Special benefits on Publication as Journal of Stem Cell Research and Therapy completes its 9 year of Publication

Image Journal of Stem Cell Research and Therapy is about to complete its 9 years of Publication in the scientific field. During the span of 9 years it has provided a large platform for scientists, scholars, researchers with ease in publication process and gained lot of reputation among the scientific community which helps the journal ... Read More