γδ T cells
γδ T cells
Gammadelta T-cells (γδT cells) were originally discovered as a result of a search for the significance of a rearranging T cell receptor (TCR) gene, γ, which did not appear to be expressed at the protein level in CD4+ or CD8+ αβTCR+ T cells. In one of two first papers that unveiled these cells, it was noted that triggering the γδTCR with an antibody to CD3 induced potent in vitro cytotoxicity against leukemic cells. Since then, accumulating studies have demonstrated that γδT cells play a critical role in cancer prevention, control and progression, by employing unique as well as overlapping immunological principles relative to αβTCR+ T cells and NK cells. Unique features include recognition by Vγ9Vδ2+ γδTCR of phosphoantigens that are increased in cancer, and of tumor-associated stress molecules such as UL16 binding protein by NKG2D. In addition, γδT cells can present tumor antigens to αβT cells to enhance their anti-tumoral activity..
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