Anaplastic Thyroid Cancer
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Anaplastic Thyroid Cancer (ATC) is a rare entity, well known for its aggressive nature, rapid progression, and extraordinal poor outcome. The median survival time from the diagnosis was reported to be <6months, with frequent resistance to conventional therapeutic approaches by surgery, radiation, or chemotherapy. No standardized effective therapeutic strategy has been documented for ATC in any guidelines due to the lack of objective data on the outcomes of practical treatment.
We demonstrated the feasibility and the efficacy of weekly Paclitaxel (wPAC) for patients with ATC in our recent clinical trial. This systemic chemotherapy was effective in approximately one-fifth of the patients, showing partial responses. The adverse events were mild and manageable, and high dose intensity could be maintained for more than eight administrations of paclitaxel (80 mg/m2 ). The effect of wPAC was clearly demonstrated when it was used as a pre-operative induction treatment as had been suggested in a case series.
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