A familial, or breed related incidence of cancer is being investigated in several breeds. These include the common disorders of lymphoma, osteosarcoma, hemangiosarcoma, melanoma, and mast cell cancer. The research is focusing on inherited mutations in tumor suppressor cells (that act to prevent cancer), or oncogenes (that promote cancer). In many cancers, genetic testing of the cells (from biopsy or removal) can allow for a more accurate prognostic indication, as well as determining whether certain drug therapies may be more appropriate than others. Special marker panels for mast cell tumors have now been developed. Genetic markers to differentiate lymphosarcomas that may be more resistant to prolonged remission are also being investigated.

Osteosarcoma is most prevalent in Great Danes, Saint Bernards, Doberman Pinchers, and Labradors. Skin and soft-tissue cancers are most prevalent in Saint Bernards, Bassett Hounds, German Shepherds, Golden Retrievers, English Setters, Great Danes, Pointers, and Flat-Coated Retrievers. Breast tumors are most prevalent in Pointers, Poodles, Pulik, Cocker Spaniels, German Shorthaired Pointers, and Boston Terriers. Melanomas are most prevalent in Scottish Terriers, German Shorthaired Pointers, Cocker Spaniels, Pointers, Weirmeraners, Golden Retrievers, and Boxers. Malignant histiocytosis occurs in Flat Coated Retrievers and Bernese Mountain Dogs. Stomach cancer occurs at a high frequency in the Chow breed. An overall reduced cancer risk is found in Dachshunds and Beagles.

Hereditary Genetics provides the rapid quarterly publication of articles in all areas related to Hereditary Genetics, genetics Disorders, mutation, cancer genetics. Hereditary Genetics welcomes the submission of manuscripts in the field of gene sequencing. Genetic syndrome, chromosomal abnormalities that meet the general criteria of significance and scientific excellence. Papers will be published approximately one month after acceptance.

Submit manuscript at https://www.longdom.org/submissions/hereditary-genetics-current-research.html