Convulsion After Poisoning of a herbicide containing Pyrazolate


Journal of Clinical Toxicology is an open access peer reviewed journal which publishes articles bi-monthly. Journal provides rapid peer review process. Recently journal has published its 2nd bi-monthly issue of its 10th volume with 5 regular articles and an editorial note.


In its 2nd issue of 10th volume Journal of Clinical Toxicology has published a case-report regarding Convulsion After Poisoning of a herbicide containing Pyrazolate and Propyrisulfuron. The cae is well reported by the author Yu Mimura, Michitaka Funayama, Naoto Yoshida, Yuji Tokuda, Taketo Takata, Masaru Mimura from Department of Neuropsychiatry, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Department of Emergency Medicine, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan.


Article is Self-poisoning with agricultural chemicals is still common and associated with suicidal behaviors in most cases. Accumulating case reports have provided knowledge about managements of certain kinds of herbicides such as organophosphate, glyphosate and glufosinate containing herbicides [1]. However, there have been no reports on poisoning with herbicide containing pyrazolate and  propyrisulfron (Pyr/Pro), which has become widely used in Japan. Although Pyr/Pro has been considered to be safe on animals, the actual effects on human bodies have not been investigated. We herein present a case with severe Pyr/Pro poisoning, who developed severe and persistent convulsions.


A 47-year-old man was transferred to the emergency room after taking most possible amount of Pyr (136.5 mg), Pro (8 mg) and water and surfactants (approximately 350 mg) containing herbicide. We had structured and systematic diagnostic approaches, which revealed no clear evidence on causes of his altered mental status other than herbicide intoxication. On arrival, he was in comatose and vital signs were normal except for his tachycardia: HR 119 /min, BP 135/81 mmHg, BT 36.7, SpO2 99% (room air). Blood glucose level was normal with 92 mg/dL. He was of average built with relatively well-nourished and had no evidence of trauma. Given his deep coma status, mechanical ventilation was administered to avoid airway obstruction. Decontamination and injection of activated charcoal were declined because one hour had already passed after ingesting the herbicide [1]. Physical examinations and laboratory examinations including renal, liver, thyroid, coagulation functions, levels of ammonia, and electrolytes were all within normal limits. Drug test using his urine (Triage DOA®) revealed no evidence of substance that could have altered the mental status. He had no history of alcohol abuse. Whole head and body CT scan was normal.

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