Journal of Tumor Research : Aromatase Inhibitors
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women and swelling of breast tissue in men. They may also be used off-label to reduce increase of oestrogen conversion during cycle with external testosterone. They may also be used for chemoprevention in high risk women.
Digital breast tomosynthesis also known as 3D mammography, is a revolutionary new screening and diagnostic breast imaging tool to improve the early detection of breast cancer. During the 3D part of the exam, an x-ray arm sweeps over the breast, taking multiple images in seconds. Images are displayed as a series of thin slices that can be viewed by our radiologists as individual images or in a dynamic interactive animation.
Cancer chemoprevention involves the chronic administration of a synthetic, natural or biological agent to reduce or delay the occurrence of malignant tumour. The potential value of this approach has been demonstrated with trials in breast, prostate and colon cancer. The paradigm for developing new chemo preventive agents has changed markedly in the last decade and now involves extensive preclinical mechanistic evaluation of agents before clinical trials are instituted and a focus on defining biomarkers of activity that can be used as early predictors of efficacy.
Oncoplastic surgery combines the latest plastic surgery techniques with breast surgical oncology. When a largely tylectomy is required that will leave the breast distorted, the remaining tissue is sculpted to realign the nipple and areola and restore a natural appearance to the breast shape. The opposing breast will also be modified to create symmetry. This is a good option for patients who are candidates for breast conservation therapy or lumpectomy, and are also candidates for breast reduction or mastopexy (breast lift).
Journal of Tumor Research